Results 101 to 110 of about 4,253,121 (312)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Exploring the Fermentation Potential of Kluyveromyces marxianus NS127 for Single-Cell Protein Production

open access: yesFermentation
Kluyveromyces marxianus is a food-grade yeast known for its diverse beneficial traits, making it an attractive candidate for both food and biotechnology applications. This study explores the potential of Kluyveromyces marxianus as a promising alternative
Lichao Dong   +7 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The Sustainable Development Commission’s commentary on JMP’s 2009 report : a review of Government travel [PDF]

open access: yes, 2012
This document is a response to 'A review of Government travel : sustainable travel engaging the public sector'.We have commented on JMP’s report A Review of Government Travel, which was commissioned jointly by the Sustainable Development Commission and ...
Sustainable Development Commission
core  

Cell culture media for cultivated meat: Review and perspectives on first principles design to drive cost-effective scale-up

open access: yesFuture Foods
Background: Cultivated meat (CM) has the potential to complement conventional meat while reducing the environmental footprint of food production to meet the growing global protein demand.
Corbin M. Goodwin   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Progress : Sustainable Development Commission critique 2004 [PDF]

open access: yes, 2012
A 2004 review of sustainable policy and practice in the UK.Publisher ...
Sustainable Development Commission
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

[SDC] [r]esponse form for the consultation on the review of the 'Strategy for sustainable construction' [PDF]

open access: yes, 2012
Our input into the 'Strategy for sustainable construction' highlights that this an important opportunity for Government to show inspirational leadership through its role as a the UK's largest construction client.Publisher ...
Sustainable Development Commission
core  

Sustainable production of myoglobin meat protein in plant chloroplasts

open access: yesFrontiers in Plant Science
Alternative routes for producing animal proteins are crucial for reducing the reliance on traditional livestock farming, which contributes significantly to greenhouse gas emissions, deforestation, and water consumption.
Alexia Groff   +9 more
doaj   +1 more source

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