Results 121 to 130 of about 4,253,121 (312)

Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A

Nature Communications
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV), shows improved efficacy.
Atsushi Yamagata, Kaori Ito, Takehiro Suzuki, Naoshi Dohmae, Tohru Terada, Mikako Shirouzu   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Sustainable development : third annual assessment of progress by the Scottish Government [PDF]

, 2012
Contents: Sustainable development : third annual assessment of progress by the Scottish Government -- Annexe 1: Scottish Government indicator and target data -- Annexe 2: Scottish Government indicator and target analysis -- Annexe 3: Delivery on ...
Sustainable Development Commission Scotland
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Effect of Particle Size on the Physical Properties of PLA/Potato Peel Composites

Compounds
In recent years, agricultural by-product fillers have been investigated in composites to influence the physical properties of the packaging material, increase biodegradability, and reduce costs.
Katharina Miller, Corina L. Reichert, Myriam Loeffler, Markus Schmid   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SDC challenge paper : measuring what matters in light of the Stiglitz Report [PDF]

, 2012
This report is based on the 'Report by the Commission on the Measurement of Economic Performance and Social Progress' (Stiglitz Report, 2009).This paper was an input to Sustainable Development Commission Scotland’s work for the Carnegie United Kingdom ...
Sustainable Development Commission Scotland
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Artificial Neural Network - Multi-Objective Genetic Algorithm based optimization for the enhanced pigment accumulation in Synechocystis sp. PCC 6803

BMC Biotechnology
Background Natural colorants produced by the cyanobacterium include carotenoids, chlorophyll a and phycocyanin. The current study used the Synechocystis sp.
Namrata Bhagat, Guddu Kumar Gupta, Amritpreet Kaur Minhas, Deepak Chhabra, Pratyoosh Shukla   +4 more
doaj   +1 more source

Species-Specific miRNAs Contribute to the Divergence between Deciduous and Evergreen Species in Ilex

Plants
MicroRNAs (miRNAs) are pivotal regulators of gene expression, playing crucial roles in plant developmental processes and environmental responses. However, the function of miRNAs in influencing deciduous traits has been little explored.
Zhonglong Guo, Zhenxiu Xu, Lei Li, Ke-Wang Xu   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Our future : different paths : the UK’s shared framework for sustainable development : [a list of promises and actions] [PDF]

, 2012
A list of 20 promises and actions from HM Government's sustainable development strategy 'One future : different paths : the UK’s shared framework for sustainable development'.Publisher ...
Sustainable Development Commission
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