Results 71 to 80 of about 4,253,121 (312)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Intravitreal hydrogels for sustained release of therapeutic proteins
Journal of Controlled Release, 2020 This review highlights how hydrogel formulations can improve intravitreal protein delivery to the posterior segment of the eye in order to increase therapeutic outcome and patient compliance. Several therapeutic proteins have shown excellent clinical successes for the treatment of various intraocular diseases.
Ilochonwu, Blessing C. +3 more
openaire +3 more sources
Sustainable communities policy review : Milton Keynes [PDF]
, 2012 This report is part of the evidence base for 'In-depth review of sustainable communities policy'.This paper collates evidence from an Sustainable Development Commission visit to Milton Keynes.Publisher ...
Sustainable Development Commission
core
Effect of Thermal Treatment on Gelling and Emulsifying Properties of Soy β-Conglycinin and Glycinin
FoodsThis study investigated the impact of different preheat treatments on the emulsifying and gel textural properties of soy protein with varying 11S/7S ratios. A mixture of 7S and 11S globulins, obtained from defatted soybean meal, was prepared at different
Wei Zhang +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Datblygu cynaliadwy a grwpiau ffydd y DU : dwy ochr yr un geiniog? : arolwg o weithgareddau datblygu cynaliadwy cymunedau ffydd y DU a’r camau nesaf ar gyfer y dyfodol [PDF]
, 2012 Report of UK faith communities and their SD activities plus next steps for the future.Welsh language version of 'Sustainable development and UK faith groups : two sides of the same coin?
World Wildlife Fund UK +1 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Sustainable communities policy review : Manchester/Salford [PDF]
, 2012 This report is part of the evidence base for 'In-depth review of sustainable communities policy'.This paper collates evidence from an Sustainable Development Commission visit, Audit Commission Manchester Salford Pathfinder reports (2003 & 2006) and ...
Sustainable Development Commission
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Consultation on developing the annual health check in 2006/2007 : response from the Sustainable Development Commission [PDF]
, 2012 Sustainable Development Commission response to the Healthcare Commission’s proposals for assessing the performance of healthcare organisations in England as set out in 'Developing the annual health check in 2006/2007'.Publisher ...
Sustainable Development Commission
core