Results 61 to 70 of about 123,234 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Spatio-temporal dynamics along the terrain gradient of diverse landscape

Journal of Environmental Engineering and Landscape Management, 2014
Land use (LU) land cover (LC) information at a temporal scale illustrates the physical coverage of the Earth’s terrestrial surface according to its use and provides the intricate information for effective planning and management activities.  LULC changes
T. V. Ramachandra, Settur Bharath, Aithal Bharath   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Funding Compromise Can Set Transportation on Path Towards Sustainability [Policy Brief] [PDF]

DTRT13-G-UTC29A number of proposals have sought to address aspects of securing or reforming state and federal transportation funding. This policy brief summarizes findings from a white paper that assembles the most prominent of these proposals and ...
National Center for Sustainable Transportation (NCST), University of California, Davis, Institute of Transportation Studies   +1 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A Funding Compromise Can Set Transportation on Path Towards Sustainability [PDF]

DTRT13-G-UTC29A number of proposals in the past year have sought to address aspects of securing or reforming state and federal transportation funding.
National Center for Sustainable Transportation (NCST), Niemeier, Deb, University of California, Davis, Institute of Transportation Studies   +2 more
core  

From Transportation Equity to Transportation Justice: Within, Through, and Beyond the State [PDF]

This manuscript version is made available under the CC BY-NC-SA 4.0 license https://creativecommons.org/licenses/by-nc-sa/4.0/. Cite as Karner, A., London, J., Rowangould, D., & Manaugh, K. (2020).
Karner, Alex A., National Center for Sustainable Transportation (NCST), London, Jonathan, Manaugh, Kevin, University of Texas at Austin, Rowangould, Dana, McGill University, University of Vermont, University of California, Davis   +8 more
core   +1 more source

Cluster analysis of potential autonomous vehicle (AV) adopters in Indonesia’s new capital

Transportation Research Interdisciplinary Perspectives
Indonesia’s major cities suffer from severe traffic congestion, leading to air pollution, wasted time, higher casualty rates, reduced productivity, respiratory issues, and contributions to global warming.
Eko Agus Prasetio, Dita Novizayanti, Aghnia Nadhira Aliya Putri   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source