Results 81 to 90 of about 4,740,554 (399)
Urban Rail Transit, 2018 Recently, automation, shared use, and electrification are viewed as the “three revolutions” in the future transportation sector, and the traditional scheduled public transit system will be greatly enhanced with flexible services and autonomous vehicle ...
Xuesong Zhou +8 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Berkeley Planning Journal, 2011 I assume we’ll want to sustain any mode of transport only if we judge it to be effective and desirable, and of course, only if we think we can afford to sustain it. Over time, we’ve abandoned any number of modes that failed those tests — horsecars, trolleycars, and pullmancars, among others; and we’ve kept those that passed the tests — most notably ...
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Combating Climate Change in the Capital of Car Culture: Part 1 [PDF]
, 2013 Say the words "Los Angeles," and you might conjure visions of epic traffic jams, air pollution so thick you can't see the hills, and a city that seems designed to intimidate and marginalize pedestrians and bicyclists.But a new reality is emerging in the ...
Varun Sivaram
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Steady-State Car-Following Time Gaps: An Empirical Study Using Naturalistic Driving Data
Journal of Advanced Transportation, 2019 The time gap is defined as the time difference between the rear of a vehicle and the front of its follower, which affects both safety and the saturation flow rate of a roadway segment.
Amara Loulizi +2 more
doaj +1 more source
Obama Administration FY 2015 Budget Proposal: Sustainable Energy, Buildings, Transportation and Climate [PDF]
, 2014 President Obama released his $3.9 trillion fiscal year (FY) 2015 budget proposal for the federal government on March 4, 2014. The budget reflects the administration's "all of the above" energy strategy as well as its reinvigorated focus on addressing ...
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Sustainable inland transportation [PDF]
Inland navigation is often mentioned as a ‘green’ alternative for the two other main inland transport modes: rail and road transport. In order to investigate the opportunities for inland navigation we first analyze the competitive position of inland ...
Beijer, C. +2 more
core +2 more sources