Results 81 to 90 of about 3,236,046 (302)

Mapping Water Quality Modelling and Catchment Management Research Trends for Sustainable Development in South Africa

Science, Engineering and Technology
Water quality degradation in river catchments remains one of the most critical environmental and infrastructural challenges facing South Africa, which mainly involves urbanisation, industrial activities, agricultural runoff, and climate variability. This
Nura Shehu Aliyu Yaro, Zesizwe Ngubane, Jacob Adedayo Adedeji   +2 more
doaj   +1 more source

The California general plan process and sustainable transportation planning [PDF]

This study reviewed the current and potential utility of California?s General Plan process as a tool for promoting more sustainable local transportation systems The study used multiple methods to investigate this issue, including:?
Duiven, Scott, United States. Department of Transportation, Wise, Lisa, Lee, Richard W., Deertrack, Judy, Wack, Paul   +5 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Purchase subsidies for 100% zero-emissions vehicle sales goals: Effectiveness, government cost, and supplier capture

Transportation Research Interdisciplinary Perspectives
Globally, purchase subsidies are among the most common policies used to support the deployment of zero-emissions vehicles (ZEVs). However, it is unclear if subsidies alone can effectively and efficiently achieve ambitious long-term ZEV sales goals, such ...
Chandan Bhardwaj, Jonn Axsen
doaj   +1 more source

Challenges and Opportunities for Integrating Climate Adaptation Efforts across State, Regional and Local Transportation Agencies [PDF]

To address the challenges posed by climate change to the transportation system, agencies are investigating climate change adaptation measures. This white paper presents a five-step framework for adapting transportation systems: inventorying and ...
University of Vermont. Transportation Research Center, National Center for Sustainable Transportation (NCST), Aultman-Hall, Lisa, Dowds, Jonathan   +3 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Microscopic mechanism and predicting calculation on mechanical properties of basalt fiber modified 3D printing cement-based materials

Case Studies in Construction Materials
This study focuses on the modification and intelligent-digital control of 3D printing materials. Based on the significant effect of basalt fiber in improving toughness, the influence mechanism of basalt fiber substitution rate, length and other factors ...
Ben Li, Kaihang Li, Xuetao Lyu, Canhao Zhao, Xianzhang Guan   +4 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source