Results 91 to 100 of about 3,236,046 (302)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deployment of Sustainable Fueling/Charging Systems at California Highway Safety Roadside Rest Areas. [PDF]

65A0527 TO 016The transportation and electricity sectors are major sources of U.S. greenhouse gas (GHG) emissions because fossil fuels are the dominant energy source for the transportation sector and for electricity generation.
National Center for Sustainable Transportation (NCST), Zhao, Hengbing, Burke, Andrew   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Intelligent Prediction of the Horizontal Deformation During the Excavation Process Based on Particle Swarm Optimisation and Support Vector Machine

The Baltic Journal of Road and Bridge Engineering
The reasonable selection of soil layer parameters relates to the accurate prediction of the horizontal deformation of the foundation pit, which is the main problem of highway tunnel pit design.
Yu Zhang, Chen Zhang, Zhiduo Zhu, Liu Yang, Hao Tang   +4 more
doaj   +1 more source

Sustainable transportation: Definitions, dimensions, and indicators - Case study of importance-performance analysis for the city of Tehran. [PDF]

Heliyon, 2023
Heidari I, Eshlaghy AT, Seyyed Hoseini SM.   +2 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Users’ Perception of Private Park and Ride Facilities in Cawang Area, Jakarta, Indonesia

Jurnal Teknik Sipil, 2019
Despite various measures implemented to manage road traffic, Jakarta City is still experiencing severe congestion. The concept, as well as the implementation of integrated urban transportation strategy, is gaining more attention in public discourse and ...
Harun al-Rasyid Lubis, Bernard Hasibuan, Muhammad Farda   +2 more
doaj  

Transportation strategy for Texas A&M University [PDF]

10727This research study produces a recommended sustainable transportation implementation plan for TexasA&M University (TAMU) to enhance the environmental performance of its campus transportation system.To achieve the goal, this study followed a ...
Lee, Jae Su, Zietsman, Josias, Farzaneh, Mohamadreza, Texas Transportation Institute, Higgins, Laura, Ramani, Tara   +5 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source