Results 91 to 100 of about 4,740,554 (399)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Spatio-temporal dynamics along the terrain gradient of diverse landscape
Journal of Environmental Engineering and Landscape Management, 2014 Land use (LU) land cover (LC) information at a temporal scale illustrates the physical coverage of the Earth’s terrestrial surface according to its use and provides the intricate information for effective planning and management activities. LULC changes
T. V. Ramachandra +2 more
doaj +1 more source
MOBILITY AND SUSTAINABLE DEVELOPMENT [PDF]
Sustainable development focuses on meeting the needs of present without compromising future generations’ prospects of meeting the same needs plus those which will be present then.
Lect. Adriana Lăzărescu, PhD. +1 more
core
Current context of transport sector in South Asia: Recommendations towards a sustainable transportation system [PDF]
, 2017 Purpose Given the current focus on sustainable development, there is a need to identify the current status of the transport sector in developing countries and the obstacles to the development of a sustainable transport system.
Amaratunga, Dilanthi +3 more
core +1 more source
Future TransportationTransportation 5.0 is an advanced and sophisticated system combining technologies with a focus on human-centered design and inclusivity. Its various components integrate intelligent infrastructure, autonomous vehicles, shared mobility services, green ...
Mohammad Shamsuddoha +2 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Enhancing Public Health Through Sustainable Urban Design: An Examination of Transportation and Green Space Integration [PDF]
, 2023 Hussein A. Al-Ansari +1 more
openalex +1 more source
Podcar City Washington, MTI Report S-13-03 [PDF]
, 2013 On October 23-25, 2013, the Mineta Transportation Institute (MTI) co-presented a two-and-one-half day conference offering insights, strategies, and opportunities for cities to develop personal rapid transit (PRT) systems in their jurisdictions. These PRT
Mineta Transportation Institute
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source