Results 41 to 50 of about 2,204,672 (307)

SUSTAINED-RELEASE FORMULATIONS FOR NIFEDIPINE

Zagazig Journal of Pharmaceutical Sciences, 1993
Three formulae of nifedipine sustained release granules were tried, each containing 10% of the drug. The former one was composed of nifedipine, lactose and PVP 40000, and prepared adopting moist granulation technique. In the second formula, the drug, PEG
Mohamed Fetouh
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

From Infection Control to Tissue Regeneration: Mechanisms, Design Strategies, and Smart Advances in Antibacterial Hydrogels

Gels
Bacterial infection, biofilm formation, and the associated oxidative stress and persistent inflammation represent major obstacles to wound healing, tissue engineering, and implantable medical devices.
Peng Liu, Lin Chen, Jinju Tian, Dan Wang, Yiping Deng, Xiangdi Jia, Zanxia Cao, Mingqiong Tong   +7 more
doaj   +1 more source

A clinical study to compare the efficacy and safety of pregabalin sustained release formulation with pregabalin immediate release formulation in patients of diabetic peripheral neuropathic pain

Indian Journal of Endocrinology and Metabolism, 2012
Objective: To compare the efficacy and safety of sustained release (SR) formulation of pregabalin with immediate release (IR) formulation in patient with diabetic peripheral neuropathic pain.
A Srivastava, S Shah, A Maseeh, B Vyasa, M Balaji, S Bhatter, P Buch, D Dantara, J Karnani, V Kumar, S Lodha, D Maji, A Moses, S Phatak, S Polarappu, S Shah, B Upadhayay   +16 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Progress of metal-organic frameworks in improving the effect of sonodynamic therapy

Biomedical Technology
Sonodynamic therapy (SDT) is a new non-invasive and precise tumor treatment method, which is a promising anticancer treatment and is becoming a cutting-edge interdisciplinary research field.
Yu Bai, Jine Wang, Ruhui Yan, Yuxian Zhao, Shuang Han, Zhichao Zhang, Yuewu Zhao   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Advances in Molecular Dynamics Simulations for Hydrogels and Nanocomposite-Reinforced Hydrogels: Multiscale Simulation Strategies and Future Directions

Gels
Hydrogels and nanocomposite−enhanced hydrogels, owing to their high−water content, excellent biocompatibility, and mechanical flexibility, have demonstrated broad application prospects in tissue engineering, drug delivery, and flexible electronics.
Lanlan Wang, Xiangling Gu, Yanyan Zhao, Jinju Tian, Xiaokun Ma, Mingqiong Tong   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Double-Emulsion Copolyester Microcapsules for Sustained Intraperitoneal Release of Carboplatin [PDF]

, 2019
Despite on-going medical advances, ovarian cancer survival rates have stagnated. In order to improve IP delivery of platinum-based antineoplastics, we aimed to develop a sustained drug delivery system for carboplatin (CPt).
Marek, Droździk, Ewa, Wiśniewska, Joanna, Łapczuk, Miroslawa, El Fray, Peter, Sobolewski, Aneta, Cymbaluk-Płoska, Anita, Chudecka-Głaz, Marcin, Frankowski   +7 more
core   +1 more source