Results 51 to 60 of about 386,974 (265)
Preparation of Alginate Microspheres for the Delivery of Risperidone
Yemeni Journal for Medical Sciences, 2014 Aim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The
Al-Tahami K.
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Long-Acting Injectable Statins—Is It Time for a Paradigm Shift?
Molecules, 2019 In recent years, advances in pharmaceutical processing technologies have resulted in development of medicines that provide therapeutic pharmacokinetic exposure for a period ranging from weeks to months following a single parenteral administration ...
Lee M. Tatham +3 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
A high-efficiency and selective fluorescent assay for the detection of tetracyclines
Scientific ReportsTetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the ...
Jingqiao Guo +7 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Sustained-Release Progesterone Vaginal Suppositories 1-Development of Sustained-Release Granule-
Biological and Pharmaceutical Bulletin, 2009 Progesterone (P) is an important hormone for the establishment of pregnancy, and its administration is useful for luteal insufficiency. Considering the problems of commercially available oral and injection drugs, hospital-formulated vaginal suppositories are clinically used.
Nakayama, Ayako +5 more
openaire +3 more sources
DEVELOPMENT AND IN VITRO ASSESSMENT OF GASTRO-RETENTIVE BILAYER FLOATING TABLET FOR MANAGING HYPERTENSION IN ACUTE CONDITIONS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityBackground: This study disseminates the formulation and in vitro assessment of bilayer floating tablets designed to be retained in the stomach, delivering a combination of amlodipine besylate and atenolol.
Aparna Datta +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source