Results 71 to 80 of about 386,974 (265)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Drug Design, Development and Therapy, 2014 Assumpta Caixàs, Lara Albert, Ismael Capel, Mercedes Rigla Endocrinology and Nutrition Department, Parc Tauli Sabadell University Hospital, Autonomous University of Barcelona, Barcelona, Spain Abstract: Obesity is an emerging disease worldwide ...
Caixàs A +3 more
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Methylphenidate and Attention Deficit Disorder
Pediatric Neurology Briefs, 1987 The relative effects of sustained release (Ritalin [SR-207[) and standard methylphenidate (Ritalin 10 mg, BD) on cognitive and social behavior in 22 boys with ADD were investigated at a summer treatment program supervised by the Western Psychiatric ...
J Gordon Millichap
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
International Journal of Nanomedicine, 2010 Heba F SalemFaculty of Pharmacy, Beni-Suef University, Beni-Suef, EgyptAbstract: The production of an intramuscular (IM) injection of natural progesterone would provide a safer solution than using semi synthetic progesterone.
Heba F Salem
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Preparation of venlafaxine hydrochloride sustained-release tablets
上海师范大学学报. 自然科学版, 2013 To prepare venlafxine hydrochloride sustained-release tablets.Hydroxypropylmethyl cellulose(HPMC) and methyl cellulose(MC) were used as main materials to prepare sustained-release tablets of velafaxine hydrochloride and the influence of important factors
GUO Lingling, SHA Na, FAN Dongli
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
3D-PRINTED MULTICOMPARTMENT TABLET WITH DUAL DRUG RELEASE BASED ON FUSED DEPOSITION MODELING [PDF]
Bulletin of Pharmaceutical Sciences. Assiut UniversityIntroduction:Three-dimensional (3D) printing is an emerging and rapidly advancing technology in the pharmaceutical field. Among the various 3D printing techniques, Fused Deposition Modeling (FDM) is widely adopted due to its simplicity, cost ...
Kuldeep Vinchurkar +3 more
doaj +1 more source