Results 61 to 70 of about 2,204,672 (307)

Tumor cells targetable graphene oxide doped microneedle for synergistic photothermal-chemotherapy treatment of melanoma

Journal of Pharmaceutical Analysis
Melanoma is characterized by high malignancy, ranking the third among skin malignancies, and is associated with lack of specific treatment options and poor prognosis. Therefore, the development of effective therapies for melanoma is imperative.
Zhiqiang Zhang, Junfang Ke, Yuxin Dai, Chenxi Fang, Yunfeng Dai, Chen Wang, Meitao Duan, Jungang Ren, Ming Chen, Chen Wang   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

High-entropy layered double hydroxide nanosheets reprogram tumor homeostasis for ultrasound-enhanced pyroptosis-mediated immunotherapy

Journal of Nanobiotechnology
Developing redox nanozymes able to disrupt cellular homeostasis and promoting immunotherapy offers great potentials to develop highly efficient cancer therapy, but remains challenging.
Xueting Yang, Manman Xu, Yashuo Jiang, Xiangling Gu, Chao Zhu, Yaqing Ge, Jing Li, Zheng Mo, Hongbin Qi, Xiaofei Liu   +9 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Preparation of protein-loaded nanoparticles based on polysuccinimide-oleylamine for sustained protein release: A two-step nanoprecipitation method

, 2023
Currently, the treatment for acute disease encompasses the use of various biological drugs (BDs). However, the utilisation of BDs is limited due to its rapid clearance and non-specific accumulation in unwanted sites which results in a lack of therapeutic
Nguyen, Nam-Trung, Chen, Xiangxun, Ta, Hang Thu, Moonshi, Shehzahdi   +3 more
core   +1 more source

Preparation of Alginate Microspheres for the Delivery of Risperidone

Yemeni Journal for Medical Sciences, 2014
Aim: The aim of this research is to prepare and evaluate alginate microspheres of prolonged delivery of a model drug, Risperidone. Methods: Alginate microspheres containing Risperidone were prepared employing cross-linking method by calcium chloride. The
Al-Tahami K.
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A high-efficiency and selective fluorescent assay for the detection of tetracyclines

Scientific Reports
Tetracyclines (TCs) rank second globally in the use of animal infection therapy and animal husbandry as growth promoters among all antibiotics. However, large amounts of TCs residue in food products and more than 75% of TCs are excreted into the ...
Jingqiao Guo, Jianhui Xin, Jine Wang, Zhen Li, Jianlei Yang, Xue Yu, Mengxia Yan, Jiangyang Mo   +7 more
doaj   +1 more source

Long-Acting Injectable Statins—Is It Time for a Paradigm Shift?

Molecules, 2019
In recent years, advances in pharmaceutical processing technologies have resulted in development of medicines that provide therapeutic pharmacokinetic exposure for a period ranging from weeks to months following a single parenteral administration ...
Lee M. Tatham, Neill J. Liptrott, Steve P. Rannard, Andrew Owen   +3 more
doaj   +1 more source