Results 141 to 150 of about 296,469 (371)

Ribosomal RNA operon copy number: A trait‐informed framework to close the microbial cultivation gap

iMetaOmics, EarlyView.
The vast majority of microbes remain uncultured, constraining functional validation and limiting microbiome‐based applications. We show that ribosomal RNA operon (rrn) copy number—a stable, phylogenetically conserved genomic trait—is strongly correlated with cultivation outcomes across ecosystems.
Yuxiao Huang, Qingliu Wu, Chang Liu, Pugang Yu, Hao Li, Shengyue Tang, Fusuo Zhang, Shuangjiang Liu, Bin Ni   +8 more
wiley   +1 more source

Effectiveness and Safety of Direct-Acting Antivirals in the Treatment of Chronic Hepatitis C: A Real-life Study in Northeastern Brazil [PDF]

Revista da Sociedade Brasileira de Medicina Tropical
Background: This study aimed to evaluate the effectiveness and safety of direct-acting antivirals (DAAs) for hepatitis C treatment by measuring sustained virologic response (SVR) and serious adverse events to help design effective interventions for ...
Elodie Bomfim Hyppolito, Alberto Novaes Ramos Jr, Larissa Peixoto Teixeira, Arthur Machado Bezerra, Lucas Arruda Mendes, Taynara Lais Silva, José Milton de Castro Lima, Érico Antonio Gomes de Arruda, Eder Janes Guerra, Maria Macedo Saraiva Tavares, Carlos Eduardo Pereira Lima, Ticiana Mota Esmeraldo, Francisco Sérgio Rangel de Paula Pessoa, Alessandra Maria Montalverne Pierre, Karla Brandão Pereira, Antônio Haroldo Araújo Filho, Lívia Melo Carone Linhares, Anderson Fuentes Ferreira, Roberto da Justa Pires Neto   +18 more
doaj   +1 more source

CD4 cell count and the risk of AIDS or death in HIV-Infected adults on combination antiretroviral therapy with a suppressed viral load: a longitudinal cohort study from COHERE. [PDF]

, 2012
BACKGROUND: Most adults infected with HIV achieve viral suppression within a year of starting combination antiretroviral therapy (cART). It is important to understand the risk of AIDS events or death for patients with a suppressed viral load.
A. Antinori, A. Antoniadou, A. Castagna, A. Castagna, A. Cozzi-Lepri, A. D’, A. Mocroft, A. Mocroft, A. Mocroft, A. Noguera-Julian, A. Phillips, A. Rauch, A. Scherrer, B. Gazzard, B. Ledergerber, C. Colin, C. Leport, C. Lewden, C. Mussini, C. Mussini, C. Sabin, C. Sabin, C. Smit, C. Stephan, C. Stephan, C. Thorne, C. Thorne, C. Torti, C. Torti, C. Torti, D. Costagliola, D. Gibb, D. Haerry, E. Girardi, F. Dabis, F. de Wolf, F. Engsig, F. Gutierrez, F. Raffi, G. Chene, G. Fatkenheuer, G. Touloumi, H. Bucher, H. Bucher, H. Bucher, H. Furrer, H. Furrer, H. Furrer, I. Weller, J. Bohlius, J. Casabona, J. Casabona, J. Del Amo, J. Ghosn, J. Ghosn, J. Grarup, J. Kjaer, J. Miro, J. Munoz, J. Ramos, J. Reekie, J. Sterne, J. Warszawski, J.M. Miro, L. Galli, L. Meyer, L. Meyer, L. Meyer, L. Wittkop, M. Battegay, M. Battegay, M. Dorrucci, M. Egger, M. Fisher, M. Garrido, M. Paulsen, M. Prins, M. Prins, M. Psichogiou, M. Puoti, M. Sharland, M. Sharland, M.M. Krause, N. Brockmeyer, N. Obel, N. Obel, N. Obel, O. Kirk, O. Kirk, O. Kirk, O. Kirk, O. Lambotte, P. Morlat, P. Reiss, P. Reiss, P. Reiss, P. Tookey, R. Lodwick, R. Paredes, R. Teira, R. Thiebaut, R. Zangerle, R. Zangerle, R.Teira, S. Ayayi, S. De Wit, S. Grabar, S. Matheron, S. Perez-Hoyos, T. Goetghebuer, V. Bouteloup, V. Le Moing, V. von Wyl, Y. Young   +113 more
core   +6 more sources

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, EarlyView.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

PEG IFN alfa-2a vs. alfa-2b: And the winner is ...? [PDF]

, 2009
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, Galati JS, Bacon BR, Davis MN, Mukhopadhyay P, Koury K,
CRAXI, Antonio
core   +1 more source

Editorial Commentary: Does HIV Remain a Risk Factor for Achieving Sustained Virologic Response Under Direct Acting Antiviral-Based Modern Hepatitis C Virus Therapy? [PDF]

, 2014
Jürgen K. Rockstroh
openalex   +1 more source

Role of PNPLA3 in the Assessment and Monitoring of Hepatic Steatosis and Fibrosis in Patients with Chronic Hepatitis C Infection Who Achieved a Sustained Virologic Response [PDF]

, 2021
Oana Irina Gavril, Lidia Iuliana Arhire, Otilia Gavrilescu, Mihaela Dranga, Oana Bărboi, Radu Sebastian Gavril, Roxana Popescu, Cristina Cijevschi Prelipcean, Anca Trifan, Cătălina Mihai   +9 more
openalex   +1 more source

Resistome flow in global landfill systems

iMetaOmics, EarlyView.
Global landfill systems represent key hubs of resistome, serving as dynamic reservoirs and amplifiers through plasmid‐driven gene mobility. Waste flows and environmental pathways sustain the transboundary resistome networks, accelerating resistance dissemination across ecosystems.
Wenqing Hong, Rui Zhang, Xiaoxing Lin, Yangqing Wang, Shu Yang, Farees ud din Mufti, Yuping Yao, Guowei Zhou, Chuanwu Xi, Weixi Shu, Gordon Price, Youcai Zhao, Liyan Song   +12 more
wiley   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, EarlyView.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Sustained Virologic Response for Chronic Hepatitis C Infection After 27 Days of Treatment with Sofosbuvir and Ribavirin

Open Forum Infectious Diseases, 2014
Successful treatment of chronic hepatitis C virus infection can now be achieved using direct-acting antiviral agents without interferon. In this report, we present a patient who achieved a sustained virologic response after 27 days of treatment with ...
Eric G. Meissner, Amy K. Nelson, Miriam M. Marti, H. Masur, A. Osinusi, S. Kottilil   +5 more
semanticscholar   +1 more source