Results 311 to 320 of about 296,469 (371)
We developed murine CMV‐based viral vectors expressing SARS‐CoV‐2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung ...
Maja Cokarić Brdovčak +9 more
wiley +1 more source
In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou +9 more
wiley +1 more source
ABSTRACT Torque teno virus (TTV) is a ubiquitous, nonenveloped DNA virus of the Anelloviridae family and a proposed surrogate marker of immune competence. Although nonpathogenic, its replication reflects host immune status and is associated with immune dysregulation during respiratory viral infections (RVIs).
Roberto Ferrarese +13 more
wiley +1 more source
ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Pâmela Ponce Martins +7 more
wiley +1 more source
ABSTRACT On the basis of gut microbiota and short‐chain fatty acids (SCFAs), this study aims to identify diagnostic biomarkers for damp‐heat diarrhea and cold‐damp diarrhea. Rat models of damp‐heat diarrhea and cold‐damp diarrhea were established. Changes in body weight, body temperature, food intake, water consumption, and the diarrhea index were ...
Hao Zhang +5 more
wiley +1 more source
Green‐synthesized AgNPs from Streptomyces sp. WSN‐2 with robust antibacterial, antifungal, and antioxidant properties, revealing a powerful and eco‐friendly route for producing bioactive nanomaterials. ABSTRACT The present study reports the isolation and molecular identification of Streptomyces sp. strain WSN‐2 using 16S rRNA gene sequencing and BLASTn
Muhammad Sultan Anjum +4 more
wiley +1 more source
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah +8 more
wiley +1 more source
This study highlights the prevalence of multidrug‐ and carbapenem‐resistant Pseudomonas aeruginosa in pediatric cystic fibrosis patients, along with the presence of carbapenemase‐encoding genes and genetic profiles, suggesting clonal spread. These findings underscore the urgent need for surveillance and strategies to combat resistant strains and ...
Erfaneh Jafari +5 more
wiley +1 more source

