Results 311 to 320 of about 296,469 (371)

Cytomegalovirus‐Based Viral Vectors Elicit Robust Systemic and Tissue‐Resident Immune Response Against SARS‐CoV‐2 Antigens

open access: yesEuropean Journal of Immunology, Volume 56, Issue 2, February 2026.
We developed murine CMV‐based viral vectors expressing SARS‐CoV‐2 spike antigen and compared immune response following intraperitoneal and intranasal delivery. Route of vaccine administration shaped antibody and CD8+ T cell response magnitude, kinetics, and tissue residency, highlighting the potential of CMV vectors for induction of protective lung ...
Maja Cokarić Brdovčak   +9 more
wiley   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug Transporters

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug candidate for the treatment of chronic hepatitis C virus infection. Potential drug–drug interactions (DDIs) of bemnifosbuvir as a substrate or perpetrator with regard to ATP‐binding cassette (ABC) and solute carrier (SLC) transporters were evaluated in vitro and in clinical studies ...
Xiao‐Jian Zhou   +9 more
wiley   +1 more source

Torque Teno Virus Levels During Viral Respiratory Infections: The Interplay With Immune Dysregulation and Coagulopathy Biomarkers

open access: yesJournal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Torque teno virus (TTV) is a ubiquitous, nonenveloped DNA virus of the Anelloviridae family and a proposed surrogate marker of immune competence. Although nonpathogenic, its replication reflects host immune status and is associated with immune dysregulation during respiratory viral infections (RVIs).
Roberto Ferrarese   +13 more
wiley   +1 more source

Metabolomic Analysis of Phytophthora parasitica Growth in the Presence of β‐sitosterol Indicates Adaptive Mechanisms Modulated by Sterols

open access: yesJournal of Basic Microbiology, Volume 66, Issue 2, February 2026.
ABSTRACT Phytophthora parasitica is a generalist phytopathogenic oomycete that infects a series of crops with great economic interest, including tomato, tobacco, and citrus species. Sterols are essential lipids in eukaryotic organisms, playing a fundamental role in the structure and function of the cell membrane.
Pâmela Ponce Martins   +7 more
wiley   +1 more source

Differentiating Damp‐Heat and Cold‐Damp Diarrhea in Rat Models via Gut Microbiota Dysbiosis and Short‐Chain Fatty Acid Profiling

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
ABSTRACT On the basis of gut microbiota and short‐chain fatty acids (SCFAs), this study aims to identify diagnostic biomarkers for damp‐heat diarrhea and cold‐damp diarrhea. Rat models of damp‐heat diarrhea and cold‐damp diarrhea were established. Changes in body weight, body temperature, food intake, water consumption, and the diarrhea index were ...
Hao Zhang   +5 more
wiley   +1 more source

An Eco‐Friendly Synthesis and Characterization of Antibacterial, Antifungal, and Antioxidant Silver Nanoparticles From Bioactive Streptomyces sp. Strain WSN‐2

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
Green‐synthesized AgNPs from Streptomyces sp. WSN‐2 with robust antibacterial, antifungal, and antioxidant properties, revealing a powerful and eco‐friendly route for producing bioactive nanomaterials. ABSTRACT The present study reports the isolation and molecular identification of Streptomyces sp. strain WSN‐2 using 16S rRNA gene sequencing and BLASTn
Muhammad Sultan Anjum   +4 more
wiley   +1 more source

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah   +8 more
wiley   +1 more source

The Burden of Antimicrobial‐Resistant Pseudomonas aeruginosa Isolates in Children With Cystic Fibrosis: Molecular Characterization and Genotyping Analysis

open access: yesMicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study highlights the prevalence of multidrug‐ and carbapenem‐resistant Pseudomonas aeruginosa in pediatric cystic fibrosis patients, along with the presence of carbapenemase‐encoding genes and genetic profiles, suggesting clonal spread. These findings underscore the urgent need for surveillance and strategies to combat resistant strains and ...
Erfaneh Jafari   +5 more
wiley   +1 more source

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