The Traditional Medicinal Plants Cuphea calophylla, Tibouchina kingii, and Pseudelephantopus spiralis Attenuate Inflammatory and Oxidative Mediators. [PDF]
Evid Based Complement Alternat Med, 2018 Aerial parts of Cuphea calophylla, Tibouchina kingii, and Pseudelephantopus spiralis have been used in Colombian traditional medicine for inflammation. However, the underlying mechanisms that could explain the anti‐inflammatory actions remain unknown.
Ramírez-Atehortúa AM +3 more
europepmc +2 more sources
3‑Benzylaminomethyl Lithocholic Acid Derivatives Exhibited Potent and Selective Uncompetitive Inhibitory Activity Against Protein Tyrosine Phosphatase 1B (PTP1B) [PDF]
ACS OmegaMaría-Eugenia Mendoza-Jasso +4 more
doaj +2 more sources
Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies. [PDF]
ChemMedChemThe indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
De-la-Cruz-Martínez L +10 more
europepmc +2 more sources
Subchronic toxicity study in rats of two new ethyl-carbamates with ixodicidal activity. [PDF]
Biomed Res Int, 2014 Female and male Wistar rats were used to determine the subchronic oral toxicities of two new ethyl‐carbamates with ixodicidal activities (ethyl‐4‐bromphenyl‐carbamate and ethyl‐4‐chlorphenyl‐carbamate). The evaluated carbamates were administered in the drinking water (12.5, 25 and 50 mg/kg/day) for 90 days.
Prado-Ochoa MG +6 more
europepmc +2 more sources
Assessment of acute oral and dermal toxicity of 2 ethyl-carbamates with activity against Rhipicephalus microplus in rats. [PDF]
Biomed Res Int, 2014 The acute oral and dermal toxicity of two new ethyl‐carbamates (ethyl‐4‐bromophenyl‐carbamate and ethyl‐4‐chlorophenyl‐carbamate) with ixodicide activity was determined in rats. The oral LD50 of each carbamate was 300 to 2000 mg/kg, and the dermal LD50 of each carbamate was >5000 mg/kg.
Prado-Ochoa MG +7 more
europepmc +2 more sources
Potencialidades de oligogalacturónidos y quitosacáridos en el enraizamiento de las plantas
Terra Latinoamericana, 2021 Los oligogalacturónidos y los quitosacáridos son miembros de una nueva clase de sustancias bioactivas en plantas que se conocen como oligosacarinas.
Juan José Reyes-Pérez +4 more
doaj +1 more source
Photoprotective and Therapeutic Potential in Skin Cancer of Amaryllidaceae Alkaloids
Proceedings, 2019 Skin cancer has evolved as the most common malignant disease, accounting for 4.5% of all new cancer cases. [...]
Carol Castañeda +5 more
doaj +1 more source
Wound healing activity of Ullucus tuberosus, an Andean tuber crop
Asian Pacific Journal of Tropical Biomedicine, 2017 Objective: This study was designed to investigate the wound healing activity of aqueous extracts of Ullucus tuberosus (U. tuberosus) using in vitro models. Methods: Lyophilized pulp and acetone extracts of U.
Nathalie Heil +4 more
doaj +1 more source
Agronomía Mesoamericana, 2023 Introducción. A partir de 1990 se ha observado un incremento en la tasa de enfermedades asociadas con dietas poco saludables y estilos de vida sedentaria, cuya atención supone un reto para los sistemas de salud. Lo anterior, ha despertado el interés por
Joel López-Mendoza +3 more
doaj +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2013 Introducción. La dihidrofolato reductasa (DHFR) se ha utilizado como blanco molecular en tratamientos antibacterianos, anticancerígenos y antipalúdicos.
Edison Osorio +4 more
doaj +1 more source