Results 41 to 50 of about 2,755 (265)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Att introducera och tillgängliggöra ämnesbegrepp i samhällskunskapsundervisning
Nordic Journal of Literacy ResearchBegreppsförståelse är en viktig del i ämneskunnandet i samhällskunskap, men kan samtidigt innebära utmaningar för elever. Syftet med den här artikeln är att bidra med kunskap om hur lärare gör för att introducera och tillgängliggöra ämnesbegrepp i ...
Yvonne Hallesson +3 more
doaj +1 more source
Grensesprengende vekkelse?
Historisk Tidsskrift, 2023 På 1820-tallet foretok flere norske haugianere reiser til Vest-Sverige for å knytte kontakt med likesinnede. Disse reisene var del av en mangeårig innsats for å utbre bevegelsen til nabolandet. Haugianerne ble tatt godt imot av både prester og lekmenn og
Jostein Garcia de Presno
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
, 2014 Rapporten är en utvärdering av en utbildnings- och rådgivningsinsats gentemot nio små livsmedelsföretag i Skåne med omnejd. FoodExport, som projektet kallas, syftade till att hjälpa företagen börja sälja på export. Utbildningen genomfördes av Exportrådet som i projektets slutskede, den 1 januari 2013, slogs samman med en annan organisation och bytte ...
Håkansson, Bengt, Adevi, Anna
openaire
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source