Results 111 to 120 of about 10,093 (306)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

POLLUTION PROBLEMS IN HUMAN ENVIRONMENT

Iranian Journal of Public Health, 1972
Since last few decades, the rapid industrialization has led to the development of many new chemicals, namely of which different kind of pesticides are of the most important ones. It is now evident that almost every food, agricultural product, water, soil
Gh. H. SANAI
doaj  

Enhancing Process Efficiency in Industry Through Statistical Process Control: Study of Aspartyl Phenylalanine Methyl Ester

Acta Natura et Scientia
Statistical Process Control (SPC) is a critical methodology within the medicinal chemical industry, employed to guarantee the safety, efficacy, and consistency of chemical products.
Mostafa Essam Eissa
doaj   +1 more source

Improving the Competency of First-Order Ontologies

, 2015
We introduce a new framework to evaluate and improve first-order (FO) ontologies using automated theorem provers (ATPs) on the basis of competency questions (CQs).
Lucio, Paqui, Rigau, German, Álvez, Javier   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

OSMODESHIDRATACIÓN DE MORA DE CASTILLA (Rubus glaucus Benth) CON TRES AGENTES EDULCORANTES OSMODEHYDRATION OF BLACKBERRY (Rubus glaucus Benth) WITH THREE SWEETENING AGENTS

Revista Facultad Nacional de Agronomía Medellín, 2004
La investigación sobre la deshidratación osmótica de mora de castilla con tres jarabes diferentes, sacarosa (js), sacarosa invertida (jsi) y miel de caña (jmc), en iguales condiciones iniciales de concentración, 70 grados Brix, temperatura promedio de 20°
Diana Patricia Giraldo Bedoya, Lina María Arango Velez, Carlos Julio Márquez Cardozo   +2 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

La Stevia rebaudiana como coadyuvante en la prevención y el control de la caries dental: una revisión de literatura

Acta Odontológica Colombiana, 2016
Introducción: La caries dental es la enfermedad crónica más prevalente en el mundo, y en Colombia, como en otros países, es considerada como un problema de salud pública.
Andrea Elena Paredes Vélez, María Claudia Naranjo Sierra   +1 more
doaj  

The use of the concept of event in enterprise ontologies and requirements engineering literature. [PDF]

The concept of event is used in a lot of meanings. It can be the possible outcome of doing something (probability theory), it can be a business transaction (accounting), or just a plain happening.
De Backer, Manu, Hens, Pieter, Poels, Geert, Snoeck, Monique   +3 more
core