Results 61 to 70 of about 10,093 (306)
Methods and compositions for stimulating T-lymphocytes [PDF]
, 2003 Disclosed are methods, compositions, antibodies, and therapeutic kits for use in stimulating cytotoxic T-lymphocytes and generating immune responses against epitopes of protooncogenes.
Fisk, Bryan A. +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Non-human tools for the evaluation of bitter taste in the design and development of medicines: a systematic review [PDF]
, 2016 Taste evaluation is a crucial factor for determining acceptance of medicines by patients. The human taste panel test is the main method used to establish the overall palatability and acceptability of a drug product to a patient towards the end of ...
Ernest, T +3 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
GELS FOR ORAL ADMINISTRATION. PART 2. EXCIPIENTS (REVIEW)
Разработка и регистрация лекарственных средств, 2019 The characteristics of the excipients as components of gels for oral administration have been considered in the article. The properties of gelatinizing, sweetening and preservation agents have been described.
E. Y. Zagorulko, A. A. Teslev
doaj
Design, formulation and evaluation of nicotine chewing gum
Advanced Biomedical Research, 2012 Background: Nicotine replacement therapy (NRT) can help smokers to quit smoking. Nicotine chewing gum has attracted the attention from pharmaceutical industries to offer it to consumers as an easily accessible NRT product.
Abolfazl Aslani, Sahar Rafiei
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Gut Microbiota—A New Concern on Health Regulation(肠道菌群：膳食与健康研究的新视角) [PDF]
Shipin kexue jishu xuebao, 2015 With the development of “Human Microbiome Project” and “Metagenomics of the Human Intestinal Tract”, great attention has been paid on human gut microbiota. With the increasing knowledge of the composition and function of gut microbiota, we found that gut
CHEN Wei(陈 卫)
doaj +1 more source
Why Didn’t Subprime Investors Demand a (Much Larger) Lemons Premium? [PDF]
, 2011 The subprime crisis would never have occurred had investors not been such enthusiastic consumers of subprime securities. The investors now say, somewhat self-servingly (but probably correctly), that they did not understand the securities -- securities ...
Hill, Claire A.
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source