Results 41 to 50 of about 29,169 (246)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Evolution of isolated turbulent trailing vortices [PDF]

, 2008
In this work, the temporal evolution of a low swirl-number turbulent Batchelor vortex is studied using pseudospectral direct numerical simulations. The solution of the governing equations in the vorticity-velocity form allows for accurate application of ...
Sanjiva K. Lele, Duraisamy, K., Lele, S., Karthik Duraisamy   +3 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Experimental Assessment of ‘subgrid’ scale Probability Density Function Models for Large Eddy Simulation [PDF]

, 2012
Filtered density functions (FDFs) of mixture fraction are quantified by analyzing experimental data obtained from two-dimensional planar laser-induced fluorescence scalar measurements in the isothermal swirling flow of a combustor operating at a ...
Hardalupas, Y., Stetsyuk, V., Taylor, A. M. K. P., Soulopoulos, N.   +3 more
core   +3 more sources

Investigation of Flame Structure and PAHs’ Evolution in a Swirl-Stabilized Spray Flame at Elevated Pressure

Energies
Swirl spray combustion has attracted significant attention due to its common usage in gas turbines. However, the high pressure in many practical applications remains a major obstacle to the deep understanding of flame stability and pollutant formation ...
Wenyu Wang, Runfan Zhu, Siyu Liu, Yong He, Wubin Weng, Shixing Wang, William L. Roberts, Zhihua Wang   +7 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Study of Silicide Formation in Large Diameter Monocrystalline Silicon

East European Journal of Physics
To study the formation of silicides, dislocation-free ingots of single-crystalline silicon with a diameter of 65÷110 mm, grown by the Czochralski method, were used.
Abdugafur T. Mamadalimov, Makhmudkhodja Sh. Isaev, Mukhammadsodik N. Mamatkulov, Sardor R. Kodirov, Jamshidjon T. Abdurazzokov   +4 more
doaj   +1 more source

The Performance of an Air-Cooled Diesel Engine with a Variable Cross-Section Dual-Channel Swirl Chamber

Energies, 2022
In order to improve the performance of a mini-type air-cooled diesel engine in terms of the overall efficiency and engine emissions, a swirl chamber of a variable cross-section dual-channel model was developed.
Lei Wu, Jun Fu, Yi Ma, Donghe Xie
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

All Swirl Is Not The Same

Journal of College Orientation, Transition, and Retention
Swirl, or the back-and-forth transfer across multiple colleges, has been the focus of policy-makers, practitioners, and researchers alike because of its empirical connections with retention and degree completion.
Diane Elliott, Sally Hyatt
doaj   +3 more sources