Results 51 to 60 of about 21,932 (307)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Theoretical and numerical investigations of swirl enhanced short natural draft dry cooling towers

, 2020
A new draft equation involving swirling motions for natural draft dry cooling towers (NDDCTs) is derived and solved analytically. A 2-D axisymmetric model for a short NDDCT is built and computational fluid dynamics (CFD) simulations are carried out to ...
Hooman, Kamel, Dai, Yuchen, Klimenko, Alexander Y, Klimenko, Alexander Y., Wang, Ying, Lu, Yuanshen   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Optimization of Hydrogen Combustion in Diesel Engines: A CFD-Based Approach for Efficient Hydrogen Mixing and Emission Reduction

Fuels
Hydrogen internal combustion engines (ICEs) have gained significant attention as a promising solution for achieving zero-carbon emissions in the transportation sector.
Bogdan Suatean, Grigore Cican, Stephane Guilain, Guillermo De-Paz-Alcolado   +3 more
doaj   +1 more source

The Performance of an Air-Cooled Diesel Engine with a Variable Cross-Section Dual-Channel Swirl Chamber

Energies, 2022
In order to improve the performance of a mini-type air-cooled diesel engine in terms of the overall efficiency and engine emissions, a swirl chamber of a variable cross-section dual-channel model was developed.
Lei Wu, Jun Fu, Yi Ma, Donghe Xie
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Inducing Swirl Flow within Stationary Cylindrical Split Channel [PDF]

, 2015
There are many free sources of energy around the globe. By investing in them, the world can reduce its dependence on fossil fuels and improve the quality of the environment.
Al-Atresh, Safia R.
core  

0/1 and 3 - dimensional cold flow analysis of a diesel engine: A case study

International Journal of Automotive Science and Technology
Gas motion in the engine cylinder plays a critical role in diesel engines' air-fuel mixing and combustion processes. Moreover, it influences the engine's performance, emissions, and heat transfer.
Gonca Kethudaoglu, Fatih Aktaş, Salih Karaaslan, Nureddin Dinler   +3 more
doaj   +1 more source

Mass transport using the series of vortex rings with swirl

Journal of Fluid Science and Technology, 2014
Behavior of the series of laminar vortex rings with circumferential flow, so-called swirl, were investigated using flow visualization, to evaluate the transport efficiency of the ejected fluid as vortex rings.
Takashi NAITOH, Nobuyuki OKURA, Osamu SUMITOMO   +2 more
doaj   +1 more source

Numerical study on the influence of pre-swirl angle on internal flow characteristics of centrifugal pumps

AIP Advances, 2022
The effect of inlet pre-swirl on the performance of a centrifugal pump is studied by numerical simulation. The governing equations are Navier–Stokes equations and the shear stress transport k–ω turbulence model.
Y. Wang, W. Xu, H. Yin, Y. Zhang, H.-S. Dou   +4 more
doaj   +1 more source