Results 61 to 70 of about 83,028 (302)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Flame–Flame Interactions and Jet–Jet Interactions in Gas Turbine Swirl Combustors

Energies
Annular combustors are widely used in newly developed aero-engines. Nevertheless, the development of annular combustors requires substantial air supplies and high-power heaters during testing, leading to high experimental costs.
Wei Wei, Xin Hui, Xin Xue, Qiang An, Shiyang Yu   +4 more
doaj   +1 more source

Thermohydraulic performance evaluation of heat exchangers equipped with centrally perforated twisted tape: Laminar and turbulent flows

Journal of Thermal Science and Technology, 2019
Convective heat transfer enhancement in a round tube mounted with a centrally perforated twisted tape (CP-TT) was numerically investigated. Influences of space of cut ratio (s/w = 0.5, 0.7 and 0.9) and twist ratio (y/w = 2.0, 3.0 and 4.0) under laminar ...
Krit RUENGPAYUNGSAK, Anucha SAYSROY, Khwanchit WONGCHAREE, Smith EIAMSA-ARD   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Numerical Investigation of Flow and Flame Structures in an Industrial Swirling Inverse Diffusion Methane/Air Burner

Fire
In this study, a novel gas burner combining air swirl and an inverse diffusion flame (IDF) is designed for industrial applications. Numerical simulations using the Reynolds-averaged Navier–Stokes (RANS) method and simplified reaction mechanisms are ...
Mengwei Sun, Yali Shao, Yu Gong, Chuanyi Xu, Tao Song, Ping Lu, Ramesh K. Agarwal   +6 more
doaj   +1 more source

Slosh alleviator Patent [PDF]

, 1969
Slosh and swirl alleviator for liquid propellant tanks during transport and ...
Nelson, W. J.
core   +1 more source

Effect of tangential swirl air inlet angle on the combustion efficiency of a hybrid powder-solid ramjet [PDF]

, 2019
A new ramjet configuration using powder and solid fuel as propellant is investigated, namely, hybrid powder-solid ramjet (HPSR). Boron particles were used as the powder in this study.
ANSYS Inc, Ao, Betelin, Cai, Chang, Chelaru, Chen, dawara, Gany, Gany, Glassman, Goroshin, Haijun Sun, Hu, Humberto Medina, Hussmann, Hussmann, Jung, Kalpakli, Kazaoka, King, Li, Li, Liang, Loftus, Magnussen, Meinköhn, Morsi, Musa, Musa, NASA, Natan, Nie, Pern, Pern, Povitsky, Rashkovskiy, Rodić, Rui Jia, Sandall, Sender, Shih, Shorr, Varghese, Wang, Xia, Xia, Xu, Yeh, Yihua Xu   +49 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source