Results 61 to 70 of about 29,169 (246)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Effects of in-cylinder flow on local heat transfer to chamber wall in diesel combustion

Nihon Kikai Gakkai ronbunshu, 2019
In order to reduce the heat loss of diesel combustion, it is important to clarify the effect of in-cylinder flow on heat transfer to the chamber wall．The experiments were conducted using the rapid compression machine (RCM) equipped with heat flux sensors
Jaehoon JEONG, Susumu SATO, Hidenori KOSAKA   +2 more
doaj   +1 more source

Risk Factors and Prognostic Value of Swirl Sign in Traumatic Acute Epidural Hematoma

Frontiers in Neurology, 2020
Objective: Acute epidural hematoma (AEDH) is one of the deadliest lesions in patients after traumatic brain injury. AEDH with swirl sign progresses rapidly and requires timely surgical treatment.
Xuanzhi Wang, Ruixiang Ge, Jinlong Yuan, Shanshui Xu, Xinggen Fang, Yi Dai, Xiaochun Jiang   +6 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Theoretical and numerical investigations of swirl enhanced short natural draft dry cooling towers

, 2020
A new draft equation involving swirling motions for natural draft dry cooling towers (NDDCTs) is derived and solved analytically. A 2-D axisymmetric model for a short NDDCT is built and computational fluid dynamics (CFD) simulations are carried out to ...
Hooman, Kamel, Dai, Yuchen, Klimenko, Alexander Y, Klimenko, Alexander Y., Wang, Ying, Lu, Yuanshen   +5 more
core   +1 more source

Thermohydraulic performance evaluation of heat exchangers equipped with centrally perforated twisted tape: Laminar and turbulent flows

Journal of Thermal Science and Technology, 2019
Convective heat transfer enhancement in a round tube mounted with a centrally perforated twisted tape (CP-TT) was numerically investigated. Influences of space of cut ratio (s/w = 0.5, 0.7 and 0.9) and twist ratio (y/w = 2.0, 3.0 and 4.0) under laminar ...
Krit RUENGPAYUNGSAK, Anucha SAYSROY, Khwanchit WONGCHAREE, Smith EIAMSA-ARD   +3 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

SWIRL GENERATION AND RECIRCULATION USING RADIAL SWIRL VANES [PDF]

, 2020
The concept of the Swirl Number and its effect on recirculation is reviewed and problems with it are identified. Swirl generation through the use of radial inlet swirl vanes is then studied.
John L Halpin
core  

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source