Results 61 to 70 of about 3,579,556 (333)

Counterrail design with increased service life for advanced turnout switches

Вестник Научно-исследовательского института железнодорожного транспорта
Introduction. Counterrail is one of the constructive elements of modern turnout switches, which requires increased service life. The impact of railway rolling stock wheels on the counterrails causes high bending stresses in the elements of attachment to ...
M. E. Berezovskii
doaj   +1 more source

Research of a Virtual Infrastructure Network with Hybrid Software-Defined Switching

Engineering Proceedings, 2023
Modern trends in the information technology have led to the fact that entire systems of infrastructure are becoming software-defined. Modern hyper-converged solutions use software-defined networking and soft switches for the hypervisor networking ...
Yuri Ushakov, Margarita Ushakova, Leonid Legashev   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets

Journal of Nanobiotechnology
Background Inclusion bodies (IBs) are well-known subcellular structures in bacteria where protein aggregates are collected. Various methods have probed their structure, but single-cell spectroscopy remains challenging.
Wouter Duverger, Grigoria Tsaka, Ladan Khodaparast, Laleh Khodaparast, Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz   +6 more
doaj   +1 more source

Cancer—A Pragmatic Switch to Combat Metabolic Syndrome?

Oncology Reviews, 2023
Both cancer and metabolic disease have become the prevalent health risks in modern societies worldwide. Cancer is a complex set of illnesses with many definitions. About 15% of cancers are caused by infections, and 10% carry a hereditary burden.
John Claras
doaj   +1 more source

New molecular switch architectures

Proceedings of the National Academy of Sciences of the United States of America, 2018
In this paper we elaborate on recently developed molecular switch architectures and how these new systems can help with the realization of new functions and advancement of artificial molecular machines.
Jared D. Harris, M. J. Moran, I. Aprahamian   +2 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

Nature Communications
Because of vectorial protein translation, residues that interact in the native protein structure but are distantly separated in the primary sequence are unavailable simultaneously.
Ramon Duran-Romaña, Bert Houben, Paula Fernández Migens, Ying Zhang, Frederic Rousseau, Joost Schymkowitz   +5 more
doaj   +1 more source

Design of switch curves geometry

Вестник Научно-исследовательского института железнодорожного транспорта
Introduction. In addition to ensuring reliability and safety, special attention should be paid to meeting the speed requirements of railway rolling stock in main lines in designing switch devices.
D. S. Ershov
doaj   +1 more source

The mixing time of the switch Markov chains: a unified approach [PDF]

, 2019
Since 1997 a considerable effort has been spent to study the mixing time of switch Markov chains on the realizations of graphic degree sequences of simple graphs.
Erdős, Péter L., Greenhill, Catherine, Mezei, Tamás Róbert, Miklós, István, Soltész, Dániel, Soukup, Lajos   +5 more
core   +2 more sources