Results 71 to 80 of about 3,579,556 (333)

The Macrophage Switch in Obesity Development

Frontiers in Immunology, 2016
Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the development of insulin resistance. In AT, the main population of leukocytes are macrophages.
Angela Castoldi, Cristiane Naffah de Souza, N. Câmara, Pedro M. Moraes-Vieira   +3 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A Preadapted Universal Switch Distribution for Testing Hilberg's Conjecture [PDF]

, 2015
Hilberg's conjecture about natural language states that the mutual information between two adjacent long blocks of text grows like a power of the block length.
Dębowski, Łukasz
core   +1 more source

To switch or not to switch: results of a nationwide guideline of mandatory switching from originator to biosimilar etanercept. One-year treatment outcomes in 2061 patients with inflammatory arthritis from the DANBIO registry

Annals of the Rheumatic Diseases, 2018
Objectives Real-world evidence on effectiveness of switching to biosimila r etanercept is scarce. In Denmark, a nationwide guideline of mandatory switch from 50 mg originator (ETA) to biosimilar (SB4) etanercept was issued for patients with rheumatoid ...
B. Glintborg, A. Loft, E. Omerovic, O. Hendricks, A. Linauskas, J. Espesen, K. Danebod, D. Jensen, H. Nordin, E. B. Dalgaard, S. Chrysidis, S. Kristensen, J. Raun, H. Lindegaard, N. Manilo, S. H. Jakobsen, I. Hansen, Dorte Dalsgaard Pedersen, I. Sørensen, L. Andersen, J. Grydehøj, F. Mehnert, N. Krogh, M. Hetland   +23 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Thermally Tuneable, Wide FSR Switch based on Micro-ring Resonators [PDF]

, 2002
A thermally tuneable, wide FSR switch, based on integrated-optic micro-ring resonators is described. This wavelength-selective switch allows high ON/OFF ratios combined with small dimensions.
Driessen, A., Geuzebroek, D.H., Kelderman, H., Klein, E.J., Klunder, D.J.W., Tan, F.S.   +5 more
core   +1 more source

Lattice-switch Monte Carlo

, 1999
We present a Monte Carlo method for the direct evaluation of the difference between the free energies of two crystal structures. The method is built on a lattice-switch transformation that maps a configuration of one structure onto a candidate ...
A. Rahman, A.D. Bruce, A.P. Lyubartsev, B. Grossmann, B. Kuchta, B.A. Berg, B.A. Berg, B.A. Berg, D. Frenkel, D. Frenkel, D. Frenkel, D.A. Young, D.A. Young, E. Marinari, G. Jacucci, G.M. Torrie, G.R. Smith, G.R. Smith, J. Piasecki, J. Zhu, K. Binder, L.V. Woodcock, L.V. Woodcock, M. Born, M. Fitzgerald, M. Parrinello, M.C. Moody, M.P. Allen, N.B. Wilding, N.W. Ashcroft, P.G. Bolhuis, P.N. Pusey, P.N. Pusey, R. Ohnesorge, R.J. Speedy, S. Pronk, S.-C. Mau, W.G. Hoover, W.G. Rudd, Y. Choi   +39 more
core   +1 more source

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch.

Genes & Development, 2002
Rho GTPases control many aspects of cell behavior through the regulation of multiple signal transduction pathways (Van Aelst and D’Souza-Schorey 1997; Hall 1998).
A. Schmidt, A. Hall
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Waveguide switch protector [PDF]

, 1972
Device for detecting excessive operation of electric motors used to drive waveguide switches is described. Purpose of device is to prevent burnout of electric motor in event of waveguide stoppage at some point other than extreme limits of travel ...
Kolbly, R. B.
core   +1 more source