Results 91 to 100 of about 712,860 (302)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Network Security Monitoring on the basis of Switches
Безопасность информационных технологий, 2013 Perspective and cost-effective approach to monitoring information security (IS) in a networked environment within the organization in the framework of its IS management, based on the use of the specialized tools network security monitoring switches is ...
Natalia Georgievna Miloslavskaya +1 more
doaj
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Robust mode conversion in NV centers using exceptional points
, 2019 We show that microwave-driven NV centers can function as topological mode switches by utilizing a special degeneracy called an exceptional point (EP). By tuning the intensities and frequencies of the driving fields, we find an EP---where two normal modes
Bar-Gill, Nir +3 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
ProceedingsIn this paper, a class of three series ohmic switches is presented, including its design principles, the simulation results, and the outcomes of the measurements performed on the first batch of fabricated samples.
Girolamo Tagliapietra +3 more
doaj +1 more source
RF phase shifter using MEMS switches on a tapered coplanar waveguide [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2012 This paper presents the analysis and design of tapered coplanar waveguide based RF phase shifter using MEMSswitches for microwave and millimeter-wave applications. The equivalent circuit of the phase shifter has been analyzed withthe capacitances of MEMS
Nataraj Boothalingam +1 more
doaj
Stability and noise in biochemical switches [PDF]
, 2000 Many processes in biology, from the regulation of gene expression in bacteria to memory in the brain, involve switches constructed from networks of biochemical reactions.
Bialek, William
core +4 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source