Results 111 to 120 of about 1,987,057 (329)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Multistage converter with reduced switch voltage stress and diode current stress

open access: yesIET Power Electronics
The utilization of switched inductors, involving parallel charging and series discharging of inductors, is extensively embraced in diverse DC–DC converters for attaining high voltage gain; nevertheless, the stress on switch voltage and diode current ...
M. S. Bhaskar   +4 more
doaj   +1 more source

Transcription switches for protoxylem and metaxylem vessel formation.

open access: yesGenes & Development, 2005
Land plants evolved xylem vessels to conduct water and nutrients, and to support the plant. Microarray analysis with a newly established Arabidopsis in vitro xylem vessel element formation system and promoter analysis revealed the possible involvement of
M. Kubo   +8 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Strategic Insights into Integrated Photonics: Core Concepts, Practical Deployments, and Future Outlook

open access: yesApplied Sciences
Integrated photonics is a cutting-edge field that merges optics and electronics on a single microchip, revolutionizing how we manipulate and transmit light.
Muhammad A. Butt, Xavier Mateos
doaj   +1 more source

Molecular Magnetic Switches

open access: yesCHIMIA, 2019
The design and synthesis of molecular switches is of growing importance considering the steep increase in the production of consumer electronics in the recent years. The function of these devices is based on binary electronic circuits and can be
Daniel Čavlović, Michal Juríček
doaj   +1 more source

“Deadman” and “Passcode” microbial kill switches for bacterial containment

open access: yesNature Chemical Biology, 2015
Biocontainment systems that couple environmental sensing with circuit-based control of cell viability could be used to prevent escape of genetically modified microbes into the environment.
C. Bashor   +4 more
semanticscholar   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Realization of a Photovoltaic Fed Sparse Alternating Current (AC)-Link Inverter

open access: yesThe Journal of Engineering Research, 2016
In this paper, a soft-switched alternating current (AC)-link buck-boost inverter with a reduced number of switches, referred to as a sparse AC-link buck-boost inverter, was designed and implemented for a photovoltaic (PV) interface. Important features of
R. Ramaprabha   +3 more
doaj   +1 more source

Coals and switches [PDF]

open access: yes
Consumption (Economics) ; Retail ...
William Burke
core  

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