Results 101 to 110 of about 295,261 (308)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Efficiency improvement and power loss breakdown for a Lundell-alternator/active-rectifier system in automotive applications [PDF]

open access: yes, 2017
A control strategy for a conventional Lundell alternator and an active-rectifier using different modulation schemes was proposed in previous work. The modulation techniques examined indicated that the system could operate more efficiently than a passive ...
Flack, Timothy J.   +5 more
core   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Reversible Mode Switching in Y coupled Terahertz Lasers [PDF]

open access: yes, 2013
Electrically independent terahertz (THz) quantum cascade lasers (QCLs) are optically coupled in a Y configuration. Dual frequency, electronically switchable emission is achieved in one QCL using an aperiodic grating, designed using computer-generated ...
Beere, Harvey E.   +4 more
core   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

OPERATING MODES OF A BRUSHLESS MAGNETOELECTRIC MECHATRONIC MODULE WITH TWO-WIRE CONTROL

open access: yesПраці Інституту електродинаміки Національної академії наук України
The paper is devoted to the study of the characteristics and operation modes of the input rectifier in the structure of the mechatronic module based on a brushless AC motor with permanent magnets when two-wire control from a power source with pulse-width
K.P. Akinin   +3 more
doaj   +1 more source

Efficiency and weight of voltage multiplier type ultra lightweight dc-dc converters [PDF]

open access: yes
An analytical and experimental study was made of a capacitor-diode voltage multiplier without a transformer which offers the possibility of high efficiency with light weight.
Harrigill, W. T., Jr., Myers, I. T.
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Advancing Discontinuous-Model Predictive Control for High Performance Inverters via Optimized Zero-Voltage State Selection Based on Offset Voltage

open access: yesApplied Sciences
Electric propulsion ships have garnered significant attention for addressing the environmental impact associated with conventional shipping vessels. Their performance critically depends on the inverters that control propulsion motors.
Eui-cheol Shin, Hyeon-gyo Chae, Chan Roh
doaj   +1 more source

A Current-Dependent Switching Strategy for Si/SiC Hybrid Switch-Based Power Converters [PDF]

open access: yes, 2017
: Hybrid switches configured by paralleling Silicon (Si) Insulated Gate Bipolar Transistors (IGBT) and Silicon Carbide (SiC) Metal-Oxide Semiconductor Field-Effect Transistors (MOSFET) have been verified to be a high-efficiency cost-effective device ...
He, Jiangbiao   +2 more
core   +1 more source

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