Results 81 to 90 of about 1,139,338 (253)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Zero-voltage transition soft-switching step-up Cuk power factor converter circuit

Scientific Reports
In conventional Cuk power factor correction (PFC) circuits, the switching devices experience high voltage and current ripples, leading to switching losses and poor power transfer capability.
Hongxing Chen, Jianwen Lin, Jian Xiao, Sijie Li, Shengbin Zhuang   +4 more
doaj   +1 more source

OPERATING MODES OF A BRUSHLESS MAGNETOELECTRIC MECHATRONIC MODULE WITH TWO-WIRE CONTROL

Праці Інституту електродинаміки Національної академії наук України
The paper is devoted to the study of the characteristics and operation modes of the input rectifier in the structure of the mechatronic module based on a brushless AC motor with permanent magnets when two-wire control from a power source with pulse-width
K.P. Akinin, V.G. Kireyev, І.S. Petukhov, A.A. Filomenko   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Markov-Switching Common Dynamic Factor Model with Mixed-Frequency Data [PDF]

In this paper, we consider a coincident economic indicator model with regime-switching dynamics and with the time series observed at different frequencies, for instance, at monthly and quarterly frequencies.
Konstantin A. KHOLODILIN
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Evaluation of switching losses in magnetic amplifiers as an alternative to IGBT switching technologies

, 2008
In future more electric aircraft (MEA) applications increased requirements of power levels stress the importance of low losses in converters and switching elements.
L. Austrin, Figueroa-Karlström, E., Engdahl, Göran,, Austrin, L., E. Figueroa-Karlstrom, G. Engdahl   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Advancing Discontinuous-Model Predictive Control for High Performance Inverters via Optimized Zero-Voltage State Selection Based on Offset Voltage

Applied Sciences
Electric propulsion ships have garnered significant attention for addressing the environmental impact associated with conventional shipping vessels. Their performance critically depends on the inverters that control propulsion motors.
Eui-cheol Shin, Hyeon-gyo Chae, Chan Roh
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source