Results 91 to 100 of about 9,405,965 (286)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
IEEE Access, 2018 This paper focuses on the design of state-dependent switching law with the dwell time restriction for interval positive switching systems. First, we present the design method of the hybrid-type state- and time-driven switching law, which inherits the two
Fangjun Luan, Juan Wang
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Switching and Signalling – The New Architecture.
, 2008 : This paper presents the new architecture of Switching and Signalling in the telecommunications for the next generation networks. It discusses both the technological and business requirements that have led to the explosion of monolithic switching ...
Switching Solutions +3 more
core
Asymptotic stability of switching systems
Electronic Journal of Differential Equations, 2010 In this article, we study the uniform asymptotic stability of the switched system $u'=f_{ u(t)}(u)$, $uin mathbb{R}^n$, where $ u:mathbb{R}_{+}o {1,2,dots,m}$ is an arbitrary piecewise constant function. We find criteria for the asymptotic stability
Driss Boularas, David Cheban
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
On Switched Hamiltonan Systems
, 2002 In this paper we study the well-posedness and stability of a class of switched linear passive systems. Instrumental in our approach is the result, also of interest in its own right, that any linear passive input-state-output system with strictly positive storage function can be written as a port-Hamiltonian system.
Gerritsen, K.M. +2 more
openaire +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
EnergiesThis study investigates the operational reliability of different types of switching substations within the context of power systems, employing the Monte Carlo method for analysis.
Franjo Pranjić, Peter Virtič
doaj +1 more source