MCT1 in Invasive Ductal Carcinoma: Monocarboxylate Metabolism and Aggressive Breast Cancer. [PDF]
, 2017 Introduction: Monocarboxylate transporter 1 (MCT1) is an importer of monocarboxylates such as lactate and pyruvate and a marker of mitochondrial metabolism.
Birbe, Ruth C. +14 more
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Conformational Space and Dynamics of Sodium-Coupled Symporters [PDF]
Biophysical Journal, 2011 Secondary transporters utilize the free energy stored in the sodium gradient to move a solute against a concentration gradient. The transport process involves a sequence of conformational changes that exposes the substrate and ion binding sites alternatively to the extracellular and the intracellular compartment.
Beckstein, O, Sansom, M
openaire +3 more sources
Molecular theranostics: principles, challenges and controversies
Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley +1 more source
Nuclear medicine in endocrine tumours [PDF]
, 2011 C
Peremans, Kathelijne +1 more
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ChemistryOpen, EarlyView.A method to detect perchlorate ions and certify safe drinking water by constructing a fluorescence‐based logic gate considering the binding of a hemicyanine dye with β‐CD is presented. Perchlorate ions (ClO4−) are prevalent contaminants in the surface, and drinking water that disrupt thyroid function by competitively inhibiting the sodium‐iodide ...
Anusha C. M. +4 more
wiley +1 more source
Use of progress curves to estimate the co-substrate-to-substrate flow ratio of a symport mechanism. Application to the isoleucine-Na+ symport of mouse ascites-tumour cells and to the lactose-proton symport [PDF]
Biochemical Journal, 1988 The model envisages two components in the process, whereby Ht equivalents of co-substrate and St equivalents of substrate accumulate in the cellular compartment in time t. The first is the flow through the symport, n equivalents of co-substrate entering or leaving with each substrate equivalent.
E.R. Johnson, P Hopkins, A A Eddy
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The Journal of Pathology, EarlyView.Abstract The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes.
Sylvia L Asa +8 more
wiley +1 more source
Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]
, 2016 Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I. +3 more
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The molecular mechanisms of defensive‐grade organic acid biosynthesis in ground beetles
Insect Molecular Biology, EarlyView.Formic acid and methacrylic acid are the primary defensive chemicals in the pygidial gland secretions of Platynus angustatus and Pterostichus moestus, respectively. Comparative transcriptomics suggests the folate cycle and valine catabolism may be involved in the biosynthesis of formic acid and methacrylic acid, respectively.
Adam M. Rork +3 more
wiley +1 more source
Quantitative RNA-seq Analysis Unveils Osmotic and Thermal Adaptation Mechanisms Relevant for Ectoine Production in Chromohalobacter salexigens [PDF]
, 2018 Quantitative RNA sequencing (RNA-seq) and the complementary phenotypic assays were implemented to investigate the transcriptional responses of Chromohalobacter salexigens to osmotic and heat stress.
Carmen Vargas +6 more
core +2 more sources