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Biology, 2023 The biological membrane surrounding all living cells forms a hydrophobic barrier to the passage of biologically important molecules. Integral membrane proteins called transporters circumvent the cellular barrier and transport molecules across the cell ...
Manuel F. Varela +4 more
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Gitelman syndrome combined with complete growth hormone deficiency [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2013 Gitelman syndrome is a rare autosomal recessive hereditary salt-losing tubulopathy, that manifests as hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria.
Se Ra Min +4 more
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Glycine Transporter 2: Mechanism and Allosteric Modulation
Frontiers in Molecular Biosciences, 2021 Neurotransmitter sodium symporters (NSS) are a subfamily of SLC6 transporters responsible for regulating neurotransmitter signalling. They are a major target for psychoactive substances including antidepressants and drugs of abuse, prompting substantial ...
Zachary J. Frangos +2 more
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Nature Communications, 2020 Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation
Kamil Gotfryd +14 more
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Journal of Fungi, 2021 The three families of yeast plasma membrane potassium influx transporters are represented in Candida albicans: Trk, Acu, and Hak proteins. Hak transporters work as K+-H+ symporters, and the genes coding for Hak proteins are transcriptionally activated ...
Francisco J. Ruiz-Castilla +3 more
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A chemiosmotic mechanism of symport [PDF]
Proceedings of the National Academy of Sciences, 2015 Lactose permease (LacY), a paradigm for the largest family of membrane transport proteins, catalyzes the coupled translocation of a galactoside and an H + across the Escherichia coli membrane (galactoside/H ...
openaire +4 more sources
The Role of Mfsd2a in Nervous System Diseases
Frontiers in Neuroscience, 2021 Major facilitator superfamily (MFS) is the maximum and most diversified membrane transporter, acting as uniporters, symporters and antiporters. MFS is considered to have a good development potential in the transport of drugs for the treatment of brain ...
Bei Huang +3 more
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A symporter’s secrets shown [PDF]
Journal of General Physiology, 2017 New JGP study explores the thermodynamic cycle and cation preference of the sugar symporter MelB.
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Communication Membrane Systems with Active Symports [PDF]
J. Autom. Lang. Comb., 2006 Journal of Automata, Languages and Combinatorics, Volume 11, Number 3, 2006, 241 ...
Robert Brijder +4 more
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Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter
Nature Communications, 2016 The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:
Christian B. Billesbølle +7 more
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