Results 21 to 30 of about 11,101 (204)

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter

Nature Communications, 2016
The neurotransmitter transporter SERT counter transport K+ to transport serotonin. Here the authors show that the activity of the prokaryotic orthologue LeuT is also modulated by this cation, suggesting a general regulatory role for K+on neutrotrasmitter:
Christian B. Billesbølle, Jonas S. Mortensen, Azmat Sohail, Solveig G. Schmidt, Lei Shi, Harald H. Sitte, Ulrik Gether, Claus J. Loland   +7 more
doaj   +1 more source

Evolutionary ancestry and novel functions of the mammalian glucose transporter (GLUT) family

BMC Evolutionary Biology, 2010
Background In general, sugar porters function by proton-coupled symport or facilitative transport modes. Symporters, coupled to electrochemical energy, transport nutrients against a substrate gradient.
Patron Nicola, Wilson-O'Brien Amy L, Rogers Suzanne   +2 more
doaj   +1 more source

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1. [PDF]

, 2017
In the human sodium glucose cotransporter (hSGLT1) cycle, the protein undergoes conformational changes where the sugar-binding site alternatively faces the external and internal surfaces.
Gorraitz, Edurne, Hirayama, Bruce A, Loo, Donald DF, Paz, Aviv, Wright, Ernest M   +4 more
core   +2 more sources

A symporter’s secrets shown [PDF]

Journal of General Physiology, 2017
New JGP study explores the thermodynamic cycle and cation preference of the sugar symporter MelB.
openaire   +2 more sources

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

Nature Communications, 2018
Neurotransmitter:sodium symporters (NSS) modulate the duration and magnitude of signaling via the sodium-coupled reuptake of neurotransmitters. Here the authors describe quantitative single molecule imaging of ligand-induced, functional dynamics of both ...
Daniel S. Terry, Rachel A. Kolster, Matthias Quick, Michael V. LeVine, George Khelashvili, Zhou Zhou, Harel Weinstein, Jonathan A. Javitch, Scott C. Blanchard   +8 more
doaj   +1 more source

Two glycerol uptake systems contribute to the high osmotolerance of Zygosaccharomyces rouxii [PDF]

, 2015
The accumulation of glycerol is essential for yeast viability upon hyperosmotic stress. Here we show that the osmotolerant yeast Zygosaccharomyces rouxii has two genes, ZrSTL1 and ZrSTL2, encoding transporters mediating the active uptake of glycerol in ...
Ahmadpour, Albertyn, Ansell, Banuelos, Brewster, Brown, Bubnova, Cherry, Czabany, Dakal, Duskova, Edgley, Emmerich, Ferreira, Ferreira, Fleet, Guldener, Hoffman, Hohmann, Inglis, Iwaki, Iwaki, Izawa, Izawa, Kayingo, Kinclova-Zimmermannova, Kinclova-Zimmermannova, Klasson, Kurtzman, Lages, Lages, Lages, Lages, Larsson, Leandro, Leandro, Leandro, Liu, Loureiro-Dias, Lucas, Maresova, Maresova, Martorell, Miesenbock, Nelissen, Neves, Onishi, Orij, Ozcan, Pahlman, Palma, Pereira, Perfect, Pribylova, Pribylova, Pribylova, Pribylova, Proft, Quain, Rep, Roberts, Saito, Serrano, Sherman, Silva-Garca, Silva-Graca, Solieri, Stribny, Tamas, Tang, Vandijken, Yamanishi, Yancey, Yancey, Zhao, Zyl, Zyl, Zyl   +77 more
core   +1 more source

Allosterically Linked Binding Sites in Serotonin Transporter Revealed by Single Molecule Force Spectroscopy

Frontiers in Molecular Biosciences, 2020
Crystal structures and experiments relying on the tools of molecular pharmacology reported conflicting results on ligand binding sites in neurotransmitter/sodium symporters (NSS). We explored the number and functionality of ligand binding sites of NSS in
Rong Zhu, Walter Sandtner, Joan E. A. Ahiable, Amy Hauck Newman, Michael Freissmuth, Harald H. Sitte, Peter Hinterdorfer   +6 more
doaj   +1 more source

Genome-wide identification of the BASS gene family in four Gossypium species and functional characterization of GhBASSs against salt stress

Scientific Reports, 2021
Bile acid sodium symporter (BASS) family proteins encode a class of sodium/solute symporters. Even though the sodium transporting property of BASSs in mammals was well studied, their sodium transportability and functional roles in plant salt tolerance ...
Thwin Myo, Fang Wei, Honghao Zhang, Jianfeng Hao, Bin Zhang, Zhixian Liu, Gangqiang Cao, Baoming Tian, Gongyao Shi   +8 more
doaj   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources

A conserved leucine occupies the empty substrate site of LeuT in the Na+-free return state

Nature Communications, 2016
Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and show ...
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen   +11 more
doaj   +1 more source