Employing information theoretic measures and mutagenesis to identify residues critical for drug-proton antiport function in Mdr1p of Candida albicans. [PDF]
PLoS ONE, 2010 By employing information theoretic measures, this study presents a structure and functional analysis of a multidrug-proton antiporter Mdr1p of Candida albicans.
Khyati Kapoor +3 more
doaj +1 more source
Frontiers in Plant Science, 2022 The oligopeptide transporter (OPT) family is a group of proton-coupled symporters that play diverse roles, including metal homeostasis. However, little is known about this family of peanuts.
Chaohui Wang +6 more
doaj +1 more source
The Jackprot Simulation Couples Mutation Rate with Natural Selection to Illustrate How Protein Evolution Is Not Random [PDF]
, 2011 Protein evolution is not a random process. Views which attribute randomness to molecular change, deleterious nature to single-gene mutations, insufficient geological time, or population size for molecular improvements to occur, or invoke “design ...
Bai, Chunyan Y. +2 more
core +2 more sources
About P systems with symport/antiport [PDF]
Soft Computing, 2004 It is proved that four membranes su±ce to P systems with minimal symport/antiport to generate all recursively enumerable sets of numbers. It is also proved that P systems with symport/antiport without maximal par- allelism are equivalent to partially blind counter automata.
openaire +3 more sources
Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE. [PDF]
PLoS Computational Biology, 2017 GLUT1 facilitates the down-gradient translocation of D-glucose across cell membrane in mammals. XylE, an Escherichia coli homolog of GLUT1, utilizes proton gradient as an energy source to drive uphill D-xylose transport.
Meng Ke +4 more
doaj +1 more source
Sodium-Assisted Formation of Binding and Traverse Conformations of the Substrate in a Neurotransmitter Sodium Symporter Model [PDF]
, 2014 Therapeutics designed to increase synaptic neurotransmitter levels by inhibiting neurotransmitter sodium sym- porters (NSSs) classify a strategic approach to treat brain disorders such as depression or epilepsy, however, the critical elementary steps ...
Bencsura, Ákos +4 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.Conventional bulk media are often unsuitable for single‐cell cultivation and analysis because they provide excess nutrients or lack essential components. Redesigning the medium allows for controlled, defined growth, enabling the development of a robust minimal medium that supports quantitative and reproducible single‐cell analysis across different ...
Judith Wegmann +5 more
wiley +1 more source
Complete mapping of substrate translocation highlights the role of LeuT N-terminal segment in regulating transport cycle. [PDF]
PLoS Computational Biology, 2014 Neurotransmitter: sodium symporters (NSSs) regulate neuronal signal transmission by clearing excess neurotransmitters from the synapse, assisted by the co-transport of sodium ions. Extensive structural data have been collected in recent years for several
Mary Hongying Cheng, Ivet Bahar
doaj +1 more source
Frontiers in Microbiology, 2023 Enterococcus is able to grow in media at pH from 5.0 to 9.0 and a high concentration of NaCl (8%). The ability to respond to these extreme conditions requires the rapid movement of three critical ions: proton (H+), sodium (Na+), and potassium (K+).
Giuliana Acciarri +10 more
doaj +1 more source
Conformational transitions of the sodium-dependent sugar transporter, vSGLT. [PDF]
, 2018 Sodium-dependent transporters couple the flow of Na+ ions down their electrochemical potential gradient to the uphill transport of various ligands. Many of these transporters share a common core structure composed of a five-helix inverted repeat and ...
Abramson, Jeff +12 more
core +1 more source