Results 121 to 130 of about 531,184 (380)

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Interpreting high levels of unfolded Von Willebrand Factor in patients with the antiphospholipid syndrome

Frontiers in Immunology
IntroductionUnfolded Von Willebrand Factor (VWF) is increased in thrombotic pathologies such as myocardial infarction. Unfolded VWF mediates the binding of platelets without the need for collagen.
Romy de Laat-Kremers, Shengshi Huang, Shengshi Huang, Hugo ten Cate, Hugo ten Cate, Marisa Ninivaggi, Bas de Laat, Bas de Laat, Katrien Devreese, Katrien Devreese   +9 more
doaj   +1 more source

Wnt-Frizzled Signaling Regulates Activity-Mediated Synapse Formation [PDF]

, 2021
Samuel Teo, Patricia C. Salinas
openalex   +1 more source

Targeting the Synapse in Alzheimer’s Disease

Frontiers in Neuroscience, 2019
Dynamic gain and loss of synapses is fundamental to healthy brain function. While Alzheimer’s Disease (AD) treatment strategies have largely focussed on beta-amyloid and tau protein pathologies, the synapse itself may also be a critical endpoint to ...
J. Jackson, E. Jambrina, Jennifer Li, H. Marston, Fiona M. Menzies, K. Phillips, G. Gilmour   +6 more
semanticscholar   +1 more source

What Is the Role of Giant Endosomal Sorting Complexes Required for Transport (ESCRT) Structures in T Cell Activation?

Advanced Biology, EarlyView.
The article explores the discovery of unusually large, ring‐shaped ESCRT protein structures formed by immune and stromal cells. It investigates their formation, composition, and potential roles in immune synapse formation. The findings challenge assumptions about their function in immunological synapses, suggesting an exclusive role in maintaining ...
Anthi Psoma, Femmy C. Stempels, Rinse de Boer, Geert van den Bogaart   +3 more
wiley   +1 more source

MorphIC: A 65-nm 738k-Synapse/mm$^2$ Quad-Core Binary-Weight Digital Neuromorphic Processor with Stochastic Spike-Driven Online Learning

, 2019
Recent trends in the field of neural network accelerators investigate weight quantization as a means to increase the resource- and power-efficiency of hardware devices. As full on-chip weight storage is necessary to avoid the high energy cost of off-chip
Bol, David, Frenkel, Charlotte, Legat, Jean-Didier   +2 more
core   +1 more source

Synergies at the synapse [PDF]

British Journal of Pharmacology, 2003
British Journal of Pharmacology (2003) 138, 1387–1388.
openaire   +2 more sources

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Signal processing in local neuronal circuits based on activity-dependent noise and competition

, 2009
We study the characteristics of weak signal detection by a recurrent neuronal network with plastic synaptic coupling. It is shown that in the presence of an asynchronous component in synaptic transmission, the network acquires selectivity with respect to
Andersen P., Bushong E., Fuhrmann G., Hagler D. J., Herbert Levine, Koch C., Vladislav Volman, Ylinen A.   +7 more
core   +1 more source

3D trigonal FAPbI₃‐based multilevel resistive switching nonvolatile memory for artificial neural synapse [PDF]

, 2023
Tao Li, Bowen Jiang, Sijie Ma, Yan Zhang, Yuanqiang Huang, Yueyi Pan, Weijun Kong, Jun Zhang, Guokun Ma, Houzhao Wan, Yong Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Hao Wang   +13 more
openalex   +1 more source