Results 291 to 300 of about 421,951 (351)

In Silico identification and modelling of FDA-approved drugs targeting T-type calcium channels. [PDF]

PLoS One
Fong P, Garcia SR, Stefan MI, Sterratt DC.   +3 more
europepmc   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Corticosterone Contributes to Context‐Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core

Advanced Science, EarlyView.
Context associated with morphine withdrawal elicits an increase in serum corticosterone levels. Corticosterone participates in CTR‐MWM by acting on MR, but not GR, in the BLA. MR in BLA→NAcC neurons mediates CTR‐MWM. MR increases presynaptic glutamate release and meanwhile participates in D1 receptor‐induced increases in presynaptic glutamate release ...
Zixuan Cao, Yaxian Wen, Yuanqi Chen, Yali Fu, Hao Yang, Chenshan Chu, Xinli Guo, Yu Yuan, Chao Lei, Huan Sheng, Da Shao, Li Yang, Dongyang Cui, Ming Chen, Bin Lai, Ping Zheng   +15 more
wiley   +1 more source

A neuromorphic processor with on-chip learning for beyond-CMOS device integration. [PDF]

Nat Commun
Greatorex H, Richter O, Mastella M, Cotteret M, Klein P, Fabre M, Rubino A, Soares Girão W, Chen J, Ziegler M, Bégon-Lours L, Indiveri G, Chicca E.   +12 more
europepmc   +1 more source

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine. [PDF]

Sci Adv
Levi LA, Inbar K, Tseiger E, Kupchik YM.
europepmc   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source

Cell-cell communication dysregulation in tuberous sclerosis complex cortical tubers and focal cortical dysplasia. [PDF]

Acta Neuropathol Commun
Scheper M, Anink JJ, Jansen FE, Van Hecke W, Mühlebner A, Mills JD, Aronica E.   +6 more
europepmc   +1 more source

Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression. [PDF]

Nat Commun
Dunworth JB, Xu Y, Graupner M, Ermentrout B, Reyes AD, Doiron B.   +5 more
europepmc   +1 more source

The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex. [PDF]

Nat Neurosci
Bodor AL, Schneider-Mizell CM, Zhang C, Elabbady L, Mallen A, Bergeson A, Brittain D, Buchanan J, Bumbarger DJ, Dalley R, Gamlin C, Joyce E, Kapner D, Kinn S, Mahalingam G, Seshamani S, Suckow S, Takeno M, Torres R, Yin W, Bae JA, Castro MA, Dorkenwald S, Halageri A, Jia Z, Jordan C, Kemnitz N, Lee K, Li K, Lu R, Macrina T, Mitchell E, Mondal SS, Mu S, Nehoran B, Popovych S, Silversmith W, Turner NL, Yu SC, Wong W, Wu J, Celii B, Campagnola L, Seeman SC, Jarsky T, Ren N, Arkhipov A, Reimer J, Seung HS, Reid RC, Collman F, da Costa NM.   +51 more
europepmc   +1 more source