Results 271 to 280 of about 279,988 (315)
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Stabilizing synapses

Science, 2021
Adenosine fine-tunes the fate of nascent synapses in brain ...
Blum, David, Lopes, LuĂ­sa
openaire   +3 more sources

The immunological synapse

Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot   +2 more
openaire   +2 more sources

The synapse in schizophrenia

European Journal of Neuroscience, 2014
AbstractIt has been several decades since synaptic dysfunction was first suggested to play a role in schizophrenia, but only in the last few years has convincing evidence been obtained as progress has been made in elucidating the genetic underpinnings of the disorder.
Andrew J, Pocklington   +2 more
openaire   +2 more sources

Mitochondria at the Synapse

The Neuroscientist, 2006
Synapses are packed with mitochondria, complex organelles with roles in energy metabolism, cell signaling, and calcium homeostasis. However, the precise mechanisms by which mitochondria influence neurotrans mission remain undefined.
Cindy V, Ly, Patrik, Verstreken
openaire   +2 more sources

THALAMOCORTICAL SYNAPSES

Progress in Neurobiology, 1997
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
openaire   +2 more sources

Ubiquitin and the synapse

Nature Reviews Neuroscience, 2002
Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections.
Ashok N, Hegde, Aaron, DiAntonio
openaire   +2 more sources

The birth of the synapse

Brain Structure and Function, 2017
It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been 'written' out of the context of neurobiology and neuronal evolution, dating back to the ...
openaire   +3 more sources

[Immunological synapses and neuronal synapses].

Medecine sciences : M/S, 2003
The interface between two cells from the immune system has recently been coined "immunological synapse". The authors review recent findings concerning the structure of the synapse formed between T lymphocytes and antigen-presenting cells. T cells can be part of different synapses, depending on the antigen-presenting cell (B cell hybridoma, proteo-lipid
Alain, Trautmann   +3 more
openaire   +1 more source

Synapsable DNA

Journal of Molecular Biology, 1996
We describe a simple innovation that allows DNA double helices to stably bind one another at specific sites, with regulatable affinity, under physiological conditions. This type of DNA synapsis requires neither an unraveling of the participating duplexes not heteroduplex formation, and is achieved by the intermolecular dimerization of short blocks of ...
E A, Venczel, D, Sen
openaire   +2 more sources

Modeling the synapse

Nature Methods, 2014
A combination of experimental protein analysis and imaging techniques is used to create a three-dimensional model of a synaptic bouton.
openaire   +2 more sources

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