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Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins
Science, 2019Coincidence detection in synaptogenesis In the brain, synaptic connections are formed with exquisite specificity, but the underlying molecular mechanisms remain largely unexplored.
Richard C. Sando, Xian Jiang, T. Südhof
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Brain Structure and Function, 2017
It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been 'written' out of the context of neurobiology and neuronal evolution, dating back to the ...
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It has long been held that the rise of neurons as a specialized cell type also marked the onset of the grand evolutionary journey for chemical synapses. Research over recent decades has shown, however, that the most dynamic chapters of synaptic history have been 'written' out of the context of neurobiology and neuronal evolution, dating back to the ...
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Advances in Materials, 2018
Just as biological synapses provide basic functions for the nervous system, artificial synaptic devices serve as the fundamental building blocks of neuromorphic networks; thus, developing novel artificial synapses is essential for neuromorphic computing.
Shuiyuan Wang +10 more
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Just as biological synapses provide basic functions for the nervous system, artificial synaptic devices serve as the fundamental building blocks of neuromorphic networks; thus, developing novel artificial synapses is essential for neuromorphic computing.
Shuiyuan Wang +10 more
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Targeting synapse function and loss for treatment of neurodegenerative diseases
Nature reviews. Drug discovery, 2023Borislav Dejanovic +2 more
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Progress in Neurobiology, 1997
Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
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Thalamocortical synapses inform the cerebral neocortex about the external and internal worlds. The thalamus produces myriad thalamocortical pathways that vary in morphological, physiological, pharmacological and functional properties. All these features are of great importance for understanding how information is acquired, integrated, processed, stored
M A, Castro-Alamancos, B W, Connors
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Nature Reviews Neuroscience, 2002
Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections.
Ashok N, Hegde, Aaron, DiAntonio
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Post-translational modification by the attachment of ubiquitin seems to have a crucial role in regulating synaptic structure and function. By controlling the stability, activity and localization of target proteins, this versatile regulatory system can shape the pattern, activity and plasticity of synaptic connections.
Ashok N, Hegde, Aaron, DiAntonio
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Piezotronic Graphene Artificial Sensory Synapse
Advanced Functional Materials, 2019The human somatosensory system, consisting of receptors, transmitters, and synapses, functions as the medium for external mechanical stimuli perception and sensing signal delivery/processing.
Youhui Chen +11 more
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Nature Reviews Neuroscience, 2009
MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation.
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MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation.
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The synapse as a treatment avenue for Alzheimer’s Disease
Molecular Psychiatry, 2022L. Peng +2 more
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