Results 1 to 10 of about 1,630,780 (295)

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways [PDF]

Nature, 2013
To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodeling. Recently microglial cells have been shown to be responsible for a portion of synaptic remodeling, but the ...
Won-Suk Chung, Gordon X Wang, Chinfei Chen   +2 more
exaly   +10 more sources

Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum [PDF]

Communications Biology
Developmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF are eliminated
Hisako Nakayama, Taisuke Miyazaki, Manabu Abe, Maya Yamazaki, Yoshinobu Kawamura, Myeongjeong Choo, Kohtarou Konno, Shinya Kawata, Naofumi Uesaka, Kouichi Hashimoto, Mariko Miyata, Kenji Sakimura, Masahiko Watanabe, Masanobu Kano   +13 more
doaj   +3 more sources

Stroke subtype-dependent synapse elimination by reactive gliosis in mice [PDF]

Nature Communications, 2021
Microglia and astrocytes clear neuronal debris after stroke, whether glia remain phagocytic and cause synapse loss at the subacute stage remains unknown.
Xiaojing Shi, Longlong Luo, Jixian Wang, Hui Shen, Yongfang Li, Muyassar Mamtilahun, Chang Liu, Rubing Shi, Joon-Hyuk Lee, Hengli Tian, Zhijun Zhang, Yongting Wang, Won-Suk Chung, Yaohui Tang, Guo-Yuan Yang   +14 more
doaj   +3 more sources

Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination. [PDF]

PLoS Biology
The optimization of brain circuit connectivity based on initial environmental input occurs during critical periods characterized by sensory experience-dependent, temporally restricted, and transiently reversible synapse elimination.
Vanessa Kay Miller, Kendal Broadie
doaj   +3 more sources

Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination [PDF]

Genome Medicine, 2022
Background Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory deficits ...
Sarah F. Rosen, Allison L. Soung, Wei Yang, Shenjian Ai, Marlene Kanmogne, Veronica A. Davé, Maxim Artyomov, Jeffrey A. Magee, Robyn S. Klein   +8 more
doaj   +3 more sources

Tumor necrosis factor alpha mediates neuromuscular synapse elimination. [PDF]

Cell Discov, 2020
During the development of mammalian neuromuscular junction (NMJ), the original supernumerary axon inputs are gradually eliminated, finally leaving each muscle fiber innervated by a single axon terminal.
Fu XQ, Peng J, Wang AH, Luo ZG.
europepmc   +5 more sources

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. [PDF]

Nat Aging, 2022
Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Dejanovic B, Wu T, Tsai MC, Graykowski D, Gandham VD, Rose CM, Bakalarski CE, Ngu H, Wang Y, Pandey S, Rezzonico MG, Friedman BA, Edmonds R, De Mazière A, Rakosi-Schmidt R, Singh T, Klumperman J, Foreman O, Chang MC, Xie L, Sheng M, Hanson JE.   +21 more
europepmc   +2 more sources

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids. [PDF]

Mol Psychiatry, 2022
Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown.
Samudyata, Oliveira AO, Malwade S, Rufino de Sousa N, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM.   +12 more
europepmc   +2 more sources

Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.

JAMA Neurol, 2023
Importance Factors associated with synapse loss beyond amyloid-β plaques and neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in Alzheimer disease (AD) and be relevant for early therapeutic intervention ...
Taddei RN, Perbet R, Mate de Gerando A, Wiedmer AE, Sanchez-Mico M, Connors Stewart T, Gaona A, Melloni A, Amaral AC, Duff K, Frosch MP, Gómez-Isla T.   +11 more
europepmc   +2 more sources

FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination [PDF]

Neurobiology of Disease, 2023
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a
Julia R. Wilkerson, Marius F. Ifrim, Arielle N. Valdez-Sinon, Patricia Hahn, Jacob E. Bowles, Gemma Molinaro, Aleksandra Janusz-Kaminska, Gary J. Bassell, Kimberly M. Huber   +8 more
doaj   +2 more sources