The homeodomain transcriptional regulator DVE-1 directs a program for synapse elimination during circuit remodeling [PDF]
Nature Communications, 2023 The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse elimination and its timing remain elusive. We show that the transcriptional regulator DVE-1, which shares homology
Kellianne D. Alexander +12 more
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Complement and microglia dependent synapse elimination in brain development. [PDF]
WIREs Mech Dis, 2022 Synapse elimination, also known as synaptic pruning, is a critical step in the maturation of neural circuits during brain development. Mounting evidence indicates that the complement cascade of the innate immune system plays an important role in synapse ...
Soteros BM, Sia GM.
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Long-term microglia depletion impairs synapse elimination and auditory brainstem function. [PDF]
Sci Rep, 2022 Specialized sound localization circuit development requires synapse strengthening, refinement, and pruning. Many of these functions are carried out by microglia, immune cells that aid in regulating neurogenesis, synaptogenesis, apoptosis, and synaptic ...
Chokr SM +4 more
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Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning [PDF]
Nature Neuroscience, 2019 Carl M Sellgren +2 more
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Local and global predictors of synapse elimination during motor learning. [PDF]
Sci AdvDuring learning, synaptic connections between excitatory neurons in the brain display considerable dynamism, with new connections being added and old connections eliminated. Synapse elimination offers an opportunity to understand the features of synapses
Hedrick NG, Wright WJ, Komiyama T.
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Activity-dependent synapse elimination requires caspase-3 activation [PDF]
eLifeDuring brain development, synapses are initially formed in excess and are later eliminated in an activity-dependent manner. Weak synapses are preferentially removed, but the mechanism linking neuronal activity to synapse removal is unclear. Here, we show
Zhou Yu +3 more
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Clec7a Worsens Long-Term Outcomes after Ischemic Stroke by Aggravating Microglia-Mediated Synapse Elimination. [PDF]
Adv Sci (Weinh)Ischemic stroke (IS) is a leading cause of morbidity and mortality globally and triggers a series of reactions leading to primary and secondary brain injuries and permanent neurological deficits. Microglia in the central nervous system play dual roles in
Wan H +11 more
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C1q and SRPX2 regulate microglia mediated synapse elimination during early development in the visual thalamus but not the visual cortex. [PDF]
Glia, 2022 The classical complement cascade mediates synapse elimination in the visual thalamus during early brain development. However, whether the primary visual cortex also undergoes complement‐mediated synapse elimination during early visual system development ...
Cong Q +5 more
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Strategies and Tools for Studying Microglial-Mediated Synapse Elimination and Refinement. [PDF]
Front Immunol, 2021 The role of microglia in controlling synapse homeostasis is becoming increasingly recognized by the scientific community. In particular, the microglia-mediated elimination of supernumerary synapses during development lays the basis for the correct ...
Morini R +4 more
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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination [PDF]
Neural Regeneration Research, 2023 During the development of the nervous system, there is an overproduction of neurons and synapses. Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or strengthening. We have
Josep Tomàs +9 more
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