Results 251 to 260 of about 1,630,780 (295)

Presynaptic Ube3a E3 ligase promotes synapse elimination through down-regulation of BMP signaling

Science, 2023
Inactivation of the ubiquitin ligase Ube3a causes the developmental disorder Angelman syndrome, whereas increased Ube3a dosage is associated with autism spectrum disorders.
Kotaro Furusawa, Kenichi Ishii, Masato Tsuji, Nagomi Tokumitsu, Eri Hasegawa, Kazuo Emoto   +5 more
semanticscholar   +1 more source

Proteolytic activity, synapse elimination, and the Hebb synapse

Journal of Neurobiology, 1994
AbstractThe Hebb synapse has been postulated to serve as a mechanism subserving both regulation of synaptic strength in the adult nervous system (long‐term potentiation and depression) and developmental activity‐dependent plasticity. According to this model, pre‐ and postsynaptic temporal concordance of activity results in strengthening of connections,
Y, Liu, R D, Fields, S, Fitzgerald, B W, Festoff, P G, Nelson   +4 more
openaire   +2 more sources

Activity-dependent elimination of neuromuscular synapses

Journal of Neurocytology, 2003
At developing neuromuscular synapses in vertebrates, different motor axon inputs to muscle fibers compete for maintenance of their synapses. Competition results in progressive changes in synaptic structure and strength that lead to the weakening and loss of some inputs, a process that has been called synapse elimination.
Ryan M, Wyatt, Rita J, Balice-Gordon
openaire   +2 more sources

Understanding Selective Synapse Elimination

Science, 2007
Synapse elimination is a hallmark of neural circuit maturation during development. Many synapses are eliminated after an initial phase of synapse formation. However, little is known about the molecular machinery that executes synaptic elimination or why certain synapses are selectively eliminated while other synapses persist and grow. Ding
openaire   +2 more sources

Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS.

Journal of Leukocyte Biology
Precise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain.
Fang-Shuai Shen, Cui Liu, Hui-Zhe Sun, Xin-Yi Chen, Yan Xue, Lei Chen   +5 more
semanticscholar   +1 more source

Synapse elimination in the central nervous system

Current Opinion in Neurobiology, 2009
Functional neural circuit formation during postnatal development involves the elimination of early-formed redundant synapses. In the neonatal mouse cerebellum, each Purkinje cell is innervated by multiple climbing fibers (CFs). Their synaptic strengths are initially uniform but one CF strengthens relative to other CFs during the first postnatal week ...
Masanobu, Kano, Kouichi, Hashimoto
openaire   +2 more sources

Synapse elimination, the size principle, and Hebbian synapses

Journal of Neurobiology, 1995
AbstractSynapse elimination at the vertebrate neuromuscular junction reduces a polyinnervated population of muscle fibers to a monoinnervated state. The function of this developmental phenomenon (if any) is unproven. A theoretical analysis of Hebbian (correlation) rules connecting presynaptic and postsynaptic activity and synaptic strength at the ...
openaire   +2 more sources

Retrograde Signaling for Climbing Fiber Synapse Elimination

The Cerebellum, 2014
Neurons form exuberant synapses with target cells early in development. Then, necessary synapses are selectively strengthened whereas unnecessary connections are weakened and eventually eliminated during postnatal development. This process is known as synapse elimination and is a crucial step for shaping immature neural circuits into functionally ...
Naofumi, Uesaka, Motokazu, Uchigashima, Takayasu, Mikuni, Hirokazu, Hirai, Masahiko, Watanabe, Masanobu, Kano   +5 more
openaire   +2 more sources

Reelin Promotes Peripheral Synapse Elimination and Maturation

Science, 2003
Reelin is an extracellular protein that is crucial for layer formation in the embryonic brain. Here, we demonstrate that Reelin functions postnatally to regulate the development of the neuromuscular junction. Reelin is required for motor end-plate maturation and proper nerve-muscle connectivity, and it directly promotes synapse elimination.
Carlo C, Quattrocchi, Cheng, Huang, Sanyong, Niu, Michael, Sheldon, David, Benhayon, Joiner, Cartwright, Dennis R, Mosier, Flavio, Keller, Gabriella, D'Arcangelo   +8 more
openaire   +2 more sources

Age‐associated synapse elimination in mouse parasympathetic ganglia

Journal of Neurobiology, 2004
AbstractLittle is known about the effects of aging on synapses in the mammalian nervous system. We examined the innervation of individual mouse submandibular ganglion (SMG) neurons for evidence of age‐related changes in synapse efficacy and number. For approximately 85% of adult life expectancy (30 months) the efficacy of synaptic transmission, as ...
Jay S, Coggan, Jaime, Grutzendler, Derron L, Bishop, Melissa R, Cook, Wenbiao, Gan, Jason, Heym, Jeff W, Lichtman   +6 more
openaire   +2 more sources