Results 261 to 270 of about 1,630,780 (295)

Neuromuscular Synapse Elimination

1982
It is well known that synaptic connections are established with a high degree of specificity during the development of the nervous system. Nonetheless, the pattern of connections at early stages of neurogenesis differs from that in the adult in several important respects.
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Vaccinia‐related kinase 2 plays a critical role in microglia‐mediated synapse elimination during neurodevelopment

Glia, 2019
During postnatal neurodevelopment, excessive synapses must be eliminated by microglia to complete the establishment of neural circuits in the brain. The lack of synaptic regulation by microglia has been implicated in neurodevelopmental disorders such as ...
Juhyun Lee, Seung-Hyun Lee, Youngjae Ryu, Dohyun Lee, Sangjune Kim, Ji-Young Seo, Eunji Oh, S. Paek, Seung U. Kim, C. Ha, Se-Young Choi, Kyong-Tai Kim   +11 more
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Phagocytic elimination of synapses by microglia during sleep

Glia, 2019
AbstractSynaptic strength reduces during sleep, but the underlying mechanisms of this process are unclear. This study showed reduction of synaptic proteins in rat prefrontal cortex (PFC) at AM7 or Zeitgeber Time (ZT0), when the light phase or sleeping period for rats started.
Mohammed E. Choudhury, Kazuya Miyanishi, Haruna Takeda, Afsana Islam, Nayu Matsuoka, Madoka Kubo, Shirabe Matsumoto, Takeharu Kunieda, Masahiro Nomoto, Hajime Yano, Junya Tanaka   +10 more
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Elimination of Synapses in the Developing Nervous System

Science, 1980
Reduction of the number of axons that contact target cells may be a general feature of neural development. This process may underlie the progressively restricted malleability of the maturing nervous system.
D, Purves, J W, Lichtman
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Synapse Elimination--For Nerves It's All or Nothing

Science, 1997
At birth, several motoneurons supply neural signals to each muscle fiber, but 2 weeks later all but the input of a single neuron is gone. This process of synapse elimination has now been carefully described in electrophysiological terms in this week's issue in a report by Colman et al . ( p. 356
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Birth, growth and elimination of a single synapse

Anatomical Science International, 2002
Synapses are functional units regulating information flows in the neuronal circuits. How synaptic junctions are formed and remodelled is a fundamental question in developmental neurobiology. In recent years, it has become possible to visualize the formation, maintenance and remodelling of a single synapse by using new imaging methods.
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Activity and synapse elimination at the neuromuscular junction

Cellular and Molecular Neurobiology, 1985
The neuromuscular junction undergoes a loss of synaptic connections during early development. This loss converts the innervation of each muscle fiber from polyneuronal to single. During this change the number of motor neurons remains constant but the number of muscle fibers innervated by each motor neuron is reduced.
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Remodeling and Elimination of Neuromuscular Synapses

1997
A large body of work has revealed that the vertebrate neuromuscular junction is a dynamic synapse, capable of dramatic structural remodeling. This was first discovered in the context of synapse elimination, the reduction in synapse number that occurs in skeletal muscles and throughout the nervous system during development.
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Emerging Roles for MFG‐E8 in Synapse Elimination

Journal of Neurochemistry
ABSTRACT Synapse elimination is an essential process in the healthy nervous system and is dysregulated in many neuropathologies. Yet, the underlying molecular mechanisms and under what conditions they occur remain unclear.
Marisa G. Aviani, Fred Menard
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Complement mediated synapse elimination in schizophrenia

2023
Schizophrenia (SCZ) is a devastating psychiatric disorder with a typically age of onset in late adolescence. The heritability is estimated to be in between 60-80% and large-scale genome-wide studies have revealed a prominent polygenic component to SCZ risk and identified more than three-hundred common risk variants.
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