Results 21 to 30 of about 1,630,780 (295)

An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum. [PDF]

Front Neural Circuits, 2021
Neuroligin is a postsynaptic cell-adhesion molecule that is involved in synapse formation and maturation by interacting with presynaptic neurexin. Mutations in neuroligin genes, including the arginine to cystein substitution at the 451st amino acid ...
Lai ESK, Nakayama H, Miyazaki T, Nakazawa T, Tabuchi K, Hashimoto K, Watanabe M, Kano M.   +7 more
europepmc   +2 more sources

Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. [PDF]

Mol Neurobiol, 2022
During the nervous system development, synapses are initially overproduced. In the neuromuscular junction (NMJ) however, competition between several motor nerve terminals and the synapses they made ends with the maturation of only one axon.
Garcia N, Hernández P, Lanuza MA, Tomàs M, Cilleros-Mañé V, Just-Borràs L, Duran-Vigara M, Polishchuk A, Balanyà-Segura M, Tomàs J.   +9 more
europepmc   +2 more sources

Protecting Connections from Synapse Elimination. [PDF]

Trends Neurosci, 2020
A recent paper by Cong et al. provides exciting evidence that neurons contain proteins that protect synapses from complement-mediated synapse elimination. SRPX2 binds C1q and blocks microglial synapse engulfment. The findings point at SRPX2, and potentially other related sushi domain proteins, as possible targets for therapies for neurodevelopmental ...
Sell GL, McAllister AK.
europepmc   +3 more sources

PKA and PKC Balance in Synapse Elimination during Neuromuscular Junction Development [PDF]

Cells, 2021
During the development of the nervous system, synaptogenesis occurs in excess though only the appropriate connections consolidate. At the neuromuscular junction, competition between several motor nerve terminals results in the maturation of a single axon
Neus Garcia, Maria A. Lanuza, Marta Tomàs, Víctor Cilleros-Mañé, Laia Just-Borràs, Maria Duran, Aleksandra Polishchuk, Josep Tomàs   +7 more
doaj   +2 more sources

The Classical Complement Cascade Mediates CNS Synapse Elimination [PDF]

Cell, 2007
During development, the formation of mature neural circuits requires the selective elimination of inappropriate synaptic connections. Here we show that C1q, the initiating protein in the classical complement cascade, is expressed by postnatal neurons in response to immature astrocytes and is localized to synapses throughout the postnatal CNS and retina.
B. Stevens, N. J. Allen, L. E. Vazquez, G. Howell, K. S. Christopherson, Navid Nouri, Kristina D. Micheva, A. Mehalow, A. Huberman, Benjamin K. Stafford, A. Sher, A. Litke, John D Lambris, Stephen J. Smith, S. John, B. Barres   +15 more
semanticscholar   +4 more sources

Reduced GABAergic inhibition and impaired synapse elimination by neuroligin-2 deletion from Purkinje cells of the developing cerebellum [PDF]

Frontiers in Neural Circuits
Functionally mature neural circuits are shaped during postnatal development by eliminating redundant synapses formed around birth. This process is known as synapse elimination and requires a proper balance of excitation and inhibition. Neuroligin-2 (NL2)
Esther Suk King Lai, Naofumi Uesaka, Naofumi Uesaka, Taisuke Miyazaki, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kano, Masanobu Kano, Masanobu Kano   +8 more
doaj   +2 more sources

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration [PDF]

Frontiers in Cellular Neuroscience, 2019
Synapse loss is an early feature shared by many neurodegenerative diseases, and it represents the major correlate of cognitive impairment. Recent studies reveal that microglia and astrocytes play a major role in synapse elimination, contributing to ...
Christopher M. Henstridge, Christopher M. Henstridge, Makis Tzioras, Makis Tzioras, Rosa C. Paolicelli   +4 more
doaj   +7 more sources

Synapse elimination and learning rules co-regulated by MHC class I H2-Db [PDF]

Nature, 2014
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC)
Hanmi Lee, Lowry A Kirkby, Marla B Feller   +2 more
exaly   +5 more sources

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development. [PDF]

Nat Neurosci, 2020
Complement-mediated synapse elimination has emerged as an important process in both brain development and neurological diseases, but whether neurons express complement inhibitors that protect synapses against complement-mediated synapse elimination ...
Cong Q, Soteros BM, Wollet M, Kim JH, Sia GM.   +4 more
europepmc   +2 more sources

Molecular and cellular mechanisms of developmental synapse elimination in the cerebellum: Involvement of autism spectrum disorder-related genes [PDF]

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Neural circuits are initially created with excessive synapse formation until around birth and undergo massive reorganization until they mature. During postnatal development, necessary synapses strengthen and remain, whereas unnecessary ones are weakened ...
Takaki WATANABE, Masanobu KANO
doaj   +2 more sources