Results 31 to 40 of about 1,630,780 (295)

The transcription factor ZFP64 promotes activity-dependent synapse elimination during postnatal cerebellar development [PDF]

iScience
Summary: Eliminating redundant synapses formed around birth is essential for shaping functionally mature neural circuits during postnatal development.
Jianling Zhang, Takaki Watanabe, Taisuke Miyazaki, Miwako Yamasaki, Kohtarou Konno, Yuto Okuno, Kyoko Matsuyama, Takayuki Noro, Masahiko Watanabe, Naofumi Uesaka, Masanobu Kano   +10 more
doaj   +2 more sources

Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

eLife, 2017
Experience and activity refine cortical circuits through synapse elimination, but little is known about the activity patterns and downstream molecular mechanisms that mediate this process.
Chia-Wei Chang, Julia R Wilkerson, Carly F Hale, Jay R Gibson, Kimberly M Huber   +4 more
doaj   +2 more sources

Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit. [PDF]

Commun Biol, 2020
The number of synapses present in a neuronal circuit is not fixed. Neurons must compensate for changes in connectivity caused by synaptic pruning, learning processes or pathological conditions through the constant adjustment of the baseline level of ...
Velasco CD, Llobet A.
europepmc   +2 more sources

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. [PDF]

Nat Neurosci, 2019
Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic connectivity. The extracellular signals, particularly neuron-derived molecules, that drive these microglial functions at synapses remain a key open question ...
Gunner G, Cheadle L, Johnson KM, Ayata P, Badimon A, Mondo E, Nagy MA, Liu L, Bemiller SM, Kim KW, Lira SA, Lamb BT, Tapper AR, Ransohoff RM, Greenberg ME, Schaefer A, Schafer DP.   +16 more
europepmc   +2 more sources

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

eLife, 2016
Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development, but the underlying mechanisms remain unclear.
Junhua Yang, Hongbin Yang, Yali Liu, Xia Li, Liming Qin, Huifang Lou, Shumin Duan, Hao Wang   +7 more
doaj   +2 more sources

Purinergic-Dependent Glial Regulation of Synaptic Plasticity of Competing Terminals and Synapse Elimination at the Neuromuscular Junction

Cell Reports, 2018
Summary: The precise wiring of synaptic connections requires the elimination of supernumerary inputs competing for innervation of the same target cell.
Houssam Darabid, Alexandre St-Pierre-See, Richard Robitaille   +2 more
doaj   +2 more sources

Neuron-Glia Signaling in Synapse Elimination.

Annual Review of Neuroscience, 2019
Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role.
D. Wilton, Lasse Dissing‐Olesen, B. Stevens   +2 more
semanticscholar   +3 more sources

Semaphorin 5B mediates synapse elimination in hippocampal neurons [PDF]

Neural Development, 2009
Background Semaphorins are known to play an important role in axon guidance and growth by triggering dynamic rearrangements of the actin cytoskeleton in the neuronal growth cone.
Currie Erin, Tapia Lucia, Wang Wenyan, Cockburn Katie, O'Connor Timothy P, Bamji Shernaz X   +5 more
doaj   +4 more sources

Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions. [PDF]

Sci Rep, 2019
Synapses undergo transition from polyinnervation by multiple axons to single innervation a few weeks after birth. Synaptic activity of axons and interaxonal competition are thought to drive this developmental synapse elimination and tested as key ...
Jung JH, Smith I, Mikesh M.
europepmc   +2 more sources

Differences in the constituent fiber types contribute to the intermuscular variation in the timing of the developmental synapse elimination. [PDF]

Sci Rep, 2019
The emergence of a mature nervous system requires a significant refinement of the synaptic connections initially formed during development. Redundant synaptic connections are removed in a process known as synapse elimination. Synapse elimination has been
Lee YI.
europepmc   +2 more sources