Results 41 to 50 of about 1,630,780 (295)

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum. [PDF]

Nat Commun, 2017
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs).
Choo M, Miyazaki T, Yamazaki M, Kawamura M, Nakazawa T, Zhang J, Tanimura A, Uesaka N, Watanabe M, Sakimura K, Kano M.   +10 more
europepmc   +2 more sources

An activity-dependent determinant of synapse elimination in the mammalian brain. [PDF]

Neuron, 2021
Yasuda M, Nagappan-Chettiar S, Johnson-Venkatesh EM, Umemori H.   +3 more
europepmc   +2 more sources

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination. [PDF]

Cells, 2019
Background: During neuromuscular junction (NMJ) development, synapses are produced in excess. By sensing the activity-dependent release of ACh, adenosine, and neurotrophins, presynaptic receptors prompt axonal competition and loss of the unnecessary ...
Garcia N, Balañà C, Lanuza MA, Tomàs M, Cilleros-Mañé V, Just-Borràs L, Tomàs J.   +6 more
europepmc   +2 more sources

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

Immunity, 2018
Irene Corradini, Valerio Zerbi, Alice Canzi   +2 more
exaly   +2 more sources

Developmental neuromuscular synapse elimination: Activity-dependence and potential downstream effector mechanisms. [PDF]

Neurosci Lett, 2020
Lee YI.
europepmc   +2 more sources

The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review

Frontiers in Cellular Neuroscience, 2022
Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people worldwide. One pathological feature of progressing AD is the loss of synapses. This is the strongest correlate of cognitive decline.
Lianne A. Hulshof, Danny van Nuijs, Elly M. Hol, Jinte Middeldorp, Jinte Middeldorp   +4 more
doaj   +1 more source

Astrocytic synapse elimination controls ocular dominance plasticity

bioRxiv, 2022
Ocular dominance plasticity (ODP) is a representative form of experience-dependent synaptic plasticity observed in the primary visual cortex (V1). However, the cellular mechanisms and physiological roles of synapse elimination in ODP are largely unknown.
Joon-Hyuk Lee, Jinah Kim, Minjin Kim, Chi-Hong Shin, Won-Suk Chung   +4 more
semanticscholar   +1 more source

Network Plasticity as Bayesian Inference [PDF]

, 2015
General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing.
Habenschuss, Stefan, Kappel, David, Legenstein, Robert, Maass, Wolfgang   +3 more
core   +6 more sources

Synapse elimination in the developing cerebellum [PDF]

Cellular and Molecular Life Sciences, 2013
Neural circuits in neonatal animals contain numerous redundant synapses that are functionally immature. During the postnatal period, unnecessary synapses are eliminated while functionally important synapses become stronger and mature. The climbing fiber (CF) to the Purkinje cell (PC) synapse is a representative model for the analysis of postnatal ...
Hashimoto, Kouichi, Kano, Masanobu
openaire   +2 more sources

PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum

Frontiers in Molecular Neuroscience, 2023
Functionally mature neural circuits are shaped during postnatal development by eliminating redundant synapses formed during the perinatal period. In the cerebellum of neonatal rodents, each Purkinje cell (PC) receives synaptic inputs from multiple (more ...
Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Takaki Watanabe, Masanobu Kano, Masanobu Kano   +9 more
doaj   +1 more source