mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
core +2 more sources
The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
core +6 more sources
Cell Reports, 2017 Experience-dependent synapse refinement is essential for functional optimization of neural circuits. However, how sensory experience sculpts excitatory synaptic transmission is poorly understood.
Kyung-Seok Han +2 more
doaj +1 more source
A simple rule for axon outgrowth and synaptic competition generates realistic connection lengths and filling fractions [PDF]
, 2009 Neural connectivity at the cellular and mesoscopic level appears very specific and is presumed to arise from highly specific developmental mechanisms.
Achacoso +64 more
core +2 more sources
The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
core +2 more sources
Temporary microglia-depletion after cosmic radiation modifies phagocytic activity and prevents cognitive deficits. [PDF]
, 2018 Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts ...
Campbell-Beachler, Mary +10 more
core +2 more sources
A one-transistor-synapse strategy for electrically-programmable massively-parallel analog array processors [PDF]
, 1997 This paper presents a linear, four-quadrants, electrically-programmable, one-transistor synapse strategy applicable to the implementation of general massively-parallel analog processors in CMOS technology.
Carmona Galán, Ricardo +3 more
core +1 more source
Astrocytes Control Synapse Formation, Function, and Elimination [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Astrocytes, through their close associations with synapses, can monitor and alter synaptic function, thus actively controlling synaptic transmission in the adult brain. Besides their important role at adult synapses, in the last three decades a number of critical findings have highlighted the importance of astrocytes in the establishment of synaptic ...
Won-Suk, Chung +2 more
openaire +2 more sources
The roles of astrocytic phagocytosis in maintaining homeostasis of brains
Journal of Pharmacological Sciences, 2021 In the central nervous system, microglia are regarded as the main cells responsible for phagocytosis, contributing to neural circuit refinement and homeostasis through synapse elimination. However, recent findings have shown that astrocytes also actively
Se Young Lee, Won-Suk Chung
doaj +1 more source
Schwann cells participate in synapse elimination at the developing neuromuscular junction. [PDF]
Curr Opin Neurobiol, 2017 Lee YI, Thompson WJ, Harlow ML.
europepmc +2 more sources