Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons. [PDF]
PLoS ONE, 2013 Synapse elimination and pruning of axon collaterals are crucial developmental events in the refinement of neuronal circuits. While a control of synapse formation by adhesion molecules is well established, the involvement of adhesion molecules in ...
Kim N Pielarski +6 more
doaj +1 more source
The role of glial cells in synapse elimination [PDF]
Current Opinion in Neurobiology, 2012 Excessive synapses generated during early development are eliminated extensively to form functionally mature neural circuits. Synapses in juvenile and mature brains are highly dynamic, and undergo remodeling processes through constant formation and elimination of dendritic spines.
Won-Suk, Chung, Ben A, Barres
openaire +2 more sources
AIMS Neuroscience, 2017 The functional role of synapse elimination has been debated since its discovery nearly three decades ago. Its widely perceived function in the removal of unnecessary and malfunctioning synapses in early life for the improvement of neural circuit ...
Yoram Baram
doaj +1 more source
Synapse elimination accompanies functional plasticity in hippocampal neurons [PDF]
Proceedings of the National Academy of Sciences, 2008 A critical component of nervous system development is synapse elimination during early postnatal life, a process known to depend on neuronal activity. Changes in synaptic strength in the form of long-term potentiation (LTP) and long-term depression (LTD) correlate with dendritic spine enlargement or shrinkage, respectively, but whether LTD can lead to ...
Natalia, Bastrikova +4 more
openaire +2 more sources
The Flip Side of Synapse Elimination [PDF]
Neuron, 2003 The fine tuning of synaptic circuits often requires an activity-dependent phase in which appropriate connections are strengthened and inappropriate connections are eliminated. In this issue of Neuron, Walsh and Lichtman propose a novel "synaptic takeover" mechanism for synapse elimination at the vertebrate NMJ, where withdrawal of one axon is ...
openaire +2 more sources
iScience, 2023 Summary: Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the ...
Joshua D. Garcia +7 more
doaj +1 more source
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco +9 more
core +3 more sources
bioRxiv, 2020 Glia contribute to synapse elimination through phagocytosis in the central nervous system. Despite important roles during development and neurological disorders, the “eat-me” signal that initiates glia-mediated phagocytosis of synapses remains largely ...
Jungjoo Park +3 more
semanticscholar +1 more source
The extent of synaptic stripping of motoneurons after axotomy is not correlated to activation of surrounding glia or downregulation of postsynaptic adhesion molecules. [PDF]
PLoS ONE, 2013 Synapse elimination in the adult central nervous system can be modelled by axotomy of spinal motoneurons which triggers removal of synapses from the cell surface of lesioned motoneurons by processes that remain elusive.
Alexander Berg +3 more
doaj +1 more source
Long Term Potentiation (LTP) and Long Term Depression (LTD) Cause Differential Spatial Redistribution of the Synaptic Vesicle Protein Synaptophysin in the Middle Molecular Layer of the Dentate Gyrus in Rat Hippocampus [PDF]
, 2016 The presynaptic modifications that accompany long-term changes in synaptic plasticity are still not fully understood. Synaptophysin is a major synaptic vesicle protein involved in neurotransmitter release. We have used quantitative electron microscopy to
Chaudhury, Sraboni +5 more
core +1 more source