Results 61 to 70 of about 233,602 (313)

Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons

Frontiers in Cellular Neuroscience, 2017
During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. Even after reaching maturity,
Saravanan Arumugam, Ana Garcera, Rosa M. Soler, Lucía Tabares   +3 more
doaj   +1 more source

Erosion of Gene Co-expression Networks Reveal Deregulation of Immune System Processes in Late-Onset Alzheimer’s Disease

Frontiers in Neuroscience, 2020
We have applied a novel and integrative analysis framework for next-generation sequencing (NGS) data to 503 human subjects provided by the Religious Orders Study and Memory and Aging Project (ROSMAP) to examine changes in transcriptomic organization and ...
John Stephen Malamon, Andres Kriete
doaj   +1 more source

The Versatile Synapse [PDF]

Journal of Experimental Biology, 1984
ABSTRACT‘Typically’ chemical synaptic transmission takes place when an influx of calcium ions during a presynaptic nerve impulse triggers exocytosis of neurotransmitter substance from synaptic vesicles. The neurotransmitter diffuses across the synaptic cleft and occupies receptors embedded in the subsynaptic membrane.
openaire   +2 more sources

The Association of Amyloid‐β and Tau With Synaptic Dysfunction in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the relative contributions of amyloid and tau to synaptic dysfunction in Alzheimer's disease (AD). Methods We included 109 cognitively unimpaired and impaired individuals from the Geneva Memory Center with available CSF synaptic biomarkers (neurogranin, SNAP‐25, GAP‐43). Participants were stratified according to amyloid (A)
Fausto Roveta, Augusto J. Mendes, Valentina Garibotto, Cecilia Boccalini, Aurelien Lathuiliere, Innocenzo Rainero, Elisa Rubino, Henrik Zetterberg, Nicholas J. Ashton, Federica Ribaldi, Giovanni B. Frisoni, for the Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

Frontiers in Pharmacology, 2020
Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown.
Dexiang Liu, Xuemei Bai, Weiwei Ma, Weiwei Ma, Danqing Xin, Xili Chu, Hongtao Yuan, Jie Qiu, Jie Qiu, HongFei Ke, Sen Yin, Wenqiang Chen, Zhen Wang   +12 more
doaj   +1 more source

The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy

Frontiers in Molecular Neuroscience, 2022
Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen, Xiaojun Hou, Xiaojun Hou, Jiao Pang, Fan Yang, Fan Yang, Angcheng Li, Suijin Lin, Na Lin, Tae Ho Lee, Hekun Liu   +10 more
doaj   +1 more source

Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]

, 2013
Direct electrical access to presynaptic ion channels has hitherto been limited to large specialized terminals such as the calyx of Held or hippocampal mossy fiber bouton.
Rusakov, Dmitri A., Korchev, Yuri E., Moss, Guy WJ, Ermolyuk, Yaroslav S, Volynski, Kirill E, Bailey, Russell J, Bailey, Russell J., Moss, Guy W.J., Klenerman, David, Volynski, Kirill E., Rusakov, Dmitri A, Novak, Pavel, Shevchuk, Andrew I, Bushby, Andrew J, Vivekananda, Umesh, Kullmann, Dimitri M., Kullmann, Dimitri M, Shevchuk, Andrew I., Gorelik, Julia, Korchev, Yuri E, Ermolyuk, Yaroslav S., Bushby, Andrew J., Benton, DCH, Caldwell, M, Moss, GWJ, Smart, TG, Robertson, AD   +26 more
core   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity

Frontiers in Computational Neuroscience, 2023
Frequency-dependent plasticity refers to changes in synaptic strength in response to different stimulation frequencies. Resonance is a factor known to be of importance in such frequency dependence, however, the role of neural noise in the process remains
Caroline A. Lea-Carnall, Lisabel I. Tanner, Marcelo A. Montemurro   +2 more
doaj   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source