Results 51 to 60 of about 304,212 (313)
Glycobiology of the synapse [PDF]
Glycobiology, 2002 Synapses are the fundamental units of connectivity that link together the nervous system. Lectin studies from 30 years ago suggested that specific glycans are concentrated at neuromuscular synapses in the peripheral nervous system and at excitatory synapses in the brain.
openaire +2 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders
Neuropsychiatric Disease and Treatment, 2023 Xiaoshan Ye,1,* Qionglin Zhou,2,* Pengcheng Ren,1,3,4 Wei Xiang,1,3 Le Xiao1 1Hainan Women and Children’s Medical Center, School of Pediatrics, Hainan Medical University, Haikou, People’s Republic of China; 2International School of Public Health ...
Ye X, Zhou Q, Ren P, Xiang W, Xiao L
doaj
Neuron, 2017 Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
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Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
Mechanisms of Anesthetic Action and Neurotoxicity: Lessons from Molluscs
Frontiers in Physiology, 2018 Anesthesia is a prerequisite for most surgical procedures in both animals and humans. Significant strides have been made in search of effective and safer compounds that elicit rapid induction and recovery from anesthesia.
Ryden Armstrong +5 more
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Advanced Functional Materials, EarlyView.An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone +11 more
wiley +1 more source
Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons
Frontiers in Cellular Neuroscience, 2017 During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. Even after reaching maturity,
Saravanan Arumugam +3 more
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Frontiers in Neuroscience, 2020 We have applied a novel and integrative analysis framework for next-generation sequencing (NGS) data to 503 human subjects provided by the Religious Orders Study and Memory and Aging Project (ROSMAP) to examine changes in transcriptomic organization and ...
John Stephen Malamon, Andres Kriete
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