Results 31 to 40 of about 304,212 (313)
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Nature Communications, 2017 Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result ...
L. Weinhard +11 more
semanticscholar +1 more source
Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2
Frontiers in Molecular Neuroscience, 2018 Structural and functional plasticity of synapses are critical neuronal mechanisms underlying learning and memory. While activity-dependent regulation of synaptic strength has been extensively studied, much less is known about the transcriptional control ...
Elodie De Bruyckere +11 more
doaj +1 more source
Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S +9 more
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The History of the Synapse [PDF]
The Anatomical Record, 2020 ABSTRACTWhy did I choose this particular topic for my lecture rather than the history of neuroscience or the history of the neuron? Simply because I believe that every disciple has the obligation to pay homage to their mentors once in their lifetime. My formation as a neuroscientist involved three such mentors spanned across three countries.
openaire +2 more sources
Autophagy at the synapse [PDF]
Neuroscience Letters, 2019 As the sites of communication between neurons, synapses depend upon precisely regulated protein-protein interactions to support neurotransmitter release and reception. Moreover, neuronal synapses typically exist great distances (i.e. up to meters) away from cell bodies, which are the sources of new proteins and the major sites of protein degradation ...
Veronica Birdsall, Clarissa L. Waites
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Learning through ferroelectric domain dynamics in solid-state synapses
Nature Communications, 2017 In the brain, learning is achieved through the ability of synapses to reconfigure the strength by which they connect neurons (synaptic plasticity). In promising solid-state synapses called memristors, conductance can be finely tuned by voltage pulses and
S. Boyn +15 more
semanticscholar +1 more source
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses
Frontiers in Neuroanatomy, 2018 Neurofilaments (NFs) are neuron-specific heteropolymers that have long been considered as structural proteins. However, it has recently been documented that they may play a functional role at synapses.
Luca Bragina +3 more
doaj +1 more source
bioRxiv, 2019 Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
S. Werneburg +12 more
semanticscholar +1 more source
HDAC6 in Diseases of Cognition and of Neurons
Cells, 2020 Central nervous system (CNS) neurodegenerative diseases are characterized by faulty intracellular transport, cognition, and aggregate regulation. Traditionally, neuroprotection exerted by histone deacetylase (HDAC) inhibitors (HDACi) has been attributed ...
Patrizia LoPresti
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Общая реаниматология, 2022 Aim of the study. To explore the structural and functional changes of neurons, glial cells, and synaptic terminals in layers I, III, and V of the sensorimotor cortex (SMC) of the rat brain after bilateral common carotid artery ligation (CCAL).Material ...
L. M. Makarieva +6 more
doaj +1 more source