Results 11 to 20 of about 214,710 (317)

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

Shiyan dongwu yu bijiao yixue, 2022
Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine ...
LIU Jiani, LIU Jiangang, WEI Yun, LI Hao, LUO Zenggang, WANG Yi, LI Kun   +6 more
doaj   +1 more source

Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex

eLife, 2016
The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it.
Onur Gökçe, Tobias Bonhoeffer, Volker Scheuss   +2 more
doaj   +1 more source

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

Cells, 2021
The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also ...
Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityatev   +6 more
doaj   +1 more source

Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration

Frontiers in Neuroscience, 2022
Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan, Ursula Püntener, Steven G. Booth, Jessica L. Teeling   +3 more
doaj   +1 more source

Huntingtin and the Synapse [PDF]

Frontiers in Cellular Neuroscience, 2021
Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT).
Barron, Jessica C., Hurley, Emily Priscilla, Parsons, Matthew P.   +2 more
openaire   +4 more sources

Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord [PDF]

, 2009
Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats.
Todd, A.J., Yasaka, T., Hughes, David I., E. Polgar, Yasaka, Toshiharu, Nagy, Gergely György, M. Watanabe, Polgár, Erika, A. J. Todd, Watanabe, Masahiko, Riddell, John S., Hughes, D.I., T. Yasaka, Todd, Andrew J., Riddell, J.S., D. I. Hughes, G. G. Nagy, Nagy, G.G., Watanabe, M., J. S. Riddell   +19 more
core   +1 more source

A VLSI array of low-power spiking neurons and bistable synapses with spike-timing dependent plasticity [PDF]

, 2006
Indiveri G, Chicca E, Douglas RJ. A VLSI array of low-power spiking neurons and bistable synapses with spike-timing dependent plasticity. IEEE Transactions on Neural Networks.
Rodney Douglas, Douglas, R. J., Indiveri, G., Giacomo Indiveri, Elisabetta Chicca, Chicca, Elisabetta ; https://orcid.org/   +5 more
core   +2 more sources

Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors

Frontiers in Synaptic Neuroscience, 2021
AMPA receptors (AMPAR) are organized into supramolecular complexes in association with other membrane proteins that provide exquisite regulation of their biophysical properties and subcellular trafficking.
Emily Eischen Martin, Erica Wleklinski, Hanh T. M. Hoang, Mohiuddin Ahmad   +3 more
doaj   +1 more source

Geometrically repatterned immunological synapses uncover formation mechanisms [PDF]

, 2006
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Michael Meyer-Hermann, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Figge, Marc Thilo, Figge Marc Thilo, Marc Thilo Figge   +5 more
core   +1 more source

The Immunological Synapse [PDF]

Cancer Immunology Research, 2003
AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
openaire   +6 more sources