Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]
, 2019 Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux +61 more
core +1 more source
A genetically encoded reporter of synaptic activity in vivo [PDF]
, 2009 To image synaptic activity within neural circuits, we tethered the genetically encoded calcium indicator (GECI) GCaMP2 to synaptic vesicles by fusion to synaptophysin. The resulting reporter, SyGCaMP2, detected the electrical activity of neurons with two
B Granseth +35 more
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Spatial representation of temporal information through spike timing dependent plasticity [PDF]
, 2003 We suggest a mechanism based on spike time dependent plasticity (STDP) of synapses to store, retrieve and predict temporal sequences. The mechanism is demonstrated in a model system of simplified integrate-and-fire type neurons densely connected by STDP ...
A. Herz +45 more
core +3 more sources
Probabilistic Fluorescence-Based Synapse Detection [PDF]
, 2016 Brain function results from communication between neurons connected by complex synaptic networks. Synapses are themselves highly complex and diverse signaling machines, containing protein products of hundreds of different genes, some in hundreds of ...
Aguerrebere, Cecilia +7 more
core +4 more sources
Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]
, 2014 Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Gorecki, Dariusz C. +3 more
core +2 more sources
Homogeneous Spiking Neuromorphic System for Real-World Pattern Recognition [PDF]
, 2015 A neuromorphic chip that combines CMOS analog spiking neurons and memristive synapses offers a promising solution to brain-inspired computing, as it can provide massive neural network parallelism and density.
Saxena, Vishal, Wu, Xinyu, Zhu, Kehan
core +3 more sources
Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Bromley, S +9 more
openaire +3 more sources
Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]
, 2013 During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV +3 more
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A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]
, 2011 The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core +1 more source
Storage Capacity of Extremely Diluted Hopfield Model
, 2004 The storage capacity of the extremely diluted Hopfield Model is studied by using Monte Carlo techniques. In this work, instead of diluting the synapses according to a given distribution, the dilution of the synapses is obtained systematically by ...
BURCU AKCAN +2 more
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