Results 71 to 80 of about 460,902 (390)

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

Neural Development, 2018
In the mammalian cerebral cortex neurons are arranged in specific layers and form connections both within the cortex and with other brain regions, thus forming a complex mesh of specialized synaptic connections comprising distinct circuits.
Isabella Farhy-Tselnicker, N. J. Allen
semanticscholar   +1 more source

Mutations in shaking-B prevent electrical synapse formation in the Drosophila giant fiber system [PDF]

, 1996
The giant fiber system (GFS) is a simple network of neurons that mediates visually elicited escape behavior in Drosophila. The giant fiber (GF), the major component of the system, is a large, descending interneuron that relays visual stimuli to the ...
Bacon, Jonathan P, Davies, Jane A, Moffat, Kevin G, Nakagawa, Madoka, O'Kane, Cahir J, Phelan, Pauline, Wilkin, Marian B   +6 more
core   +2 more sources

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation

Frontiers in Molecular Neuroscience, 2017
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system.
Rui P. A. Tan, Iryna Leshchyns’ka, Vladimir Sytnyk   +2 more
doaj   +1 more source

Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2020
Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease ...
Catarina Perdigão, Mariana A. Barata, Margarida N. Araújo, Farzaneh S. Mirfakhar, Jorge Castanheira, Cláudia Guimas Almeida   +5 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia [PDF]

, 2019
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
A.M. Lavoie, AR Woodruff, C Börgers, C-G Hahn, CA Brenner, Chi-Ming A. Chen, CL Beasley, D Vierling-Claassen, D Vierling-Claassen, David A. Lewis, David W. Volk, E Salinas, G Gonzalez-Burgos, GA Light, GP Krishnan, Hanna Thuné, Henry Markram, I Wonodi, J. Szabadics, Joshua T. Kantrowitz, JS Kwon, KM Spencer, KM Spencer, KM Spencer, L KRISTIANSEN, LS Overstreet, M Bartos, M Carlén, Monica Beneyto, Monika P. Jadi, MW Howard, N Hajos, Nadezhda V. Povysheva, P Fries, P Steullet, P Teale, Pascal Fries, R Tsuchimoto, Robin Tremblay, RY Cho, S Keros, T Hashimoto, T Mäki-Marttunen, T-U Woo, Tuomo Mäki-Marttunen, Y Kawaguchi   +45 more
core   +2 more sources

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Polyoxometalates‐Modulated Reduced Graphene Oxide Flash Memory with Ambipolar Trapping as Bidirectional Artificial Synapse

Advanced Electronic Materials, 2018
Employing flash memories that function as the analogue synapse cleft for implementation of neural systems is a popular approach. For practical application in synapse mimicking, ambipolar trapping of both holes and electrons enables the weight updated ...
Xiaoli Chen, Jingyi Pan, Jingjing Fu, Xin Zhu, Chen Zhang, Li Zhou, Yan Wang, Ziyu Lv, Ye Zhou, Su‐Ting Han   +9 more
doaj   +1 more source

Aligning a Synapse [PDF]

Neuron, 2017
Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
openaire   +2 more sources