Results 81 to 90 of about 445,271 (401)

Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome. [PDF]

, 2019
Fragile X Syndrome (FXS), a common inheritable form of intellectual disability, is known to alter neocortical circuits. However, its impact on the diverse synapse types comprising these circuits, or on the involvement of astrocytes, is not well known. We
Madison, Daniel V, Micheva, Kristina D, Perez, Marc M, Sapiro, Guillermo, Simhal, Anish K, Zuo, Yi   +5 more
core   +1 more source

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

Advanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier, Esra Türker, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Panthipa Suwannakot, Benedikt Gantert, Abhinav Singh, Vanessa Moessler, Annemarie Sodmann, Nicoletta Murenu, Joachim Schenk, Natascha Schaefer, Torsten Blunk, Aldo R. Boccaccini, Tessa C. Lühmann, Jörg Tessmar, Jeremy M. Crook, Eva Tomaskovic‐Crook, Paul D. Dalton, Gregor Lang, Robert Blum, Reiner Strick, Silvia Budday, Katrin G. Heinze, Carmen Villmann   +26 more
wiley   +1 more source

Neuron Class and Target Variability in the Three-Dimensional Localization of SK2 Channels in Hippocampal Neurons as Detected by Immunogold FIB-SEM

Frontiers in Neuroanatomy, 2021
Small-conductance calcium-activated potassium (SK) channels are crucial for learning and memory. However, many aspects of their spatial organization in neurons are still unknown.
Rafael Luján, Angel Merchán-Pérez, Joaquim Soriano, Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Javier DeFelipe, Javier DeFelipe   +8 more
doaj   +1 more source

Electrically Induced Negative Differential Resistance States Mediated by Oxygen Octahedra Coupling in Manganites for Neuronal Dynamics

Advanced Functional Materials, EarlyView.
The negative differential resistance is exploited, using a La0.67Sr0.33MnO3 thin film network to demonstrate various neuronal functionalities of the human brain, such as leaky‐integrate‐fire and oscillatory patterns. Transmission electron microscope studies show local modification in oxygen octahedra in the network leads to co‐existing phases ...
Azminul Jaman, Lorenzo Fratino, Majid Ahmadi, Rodolfo Rocco, Bart J. Kooi, Marcelo Rozenberg, Tamalika Banerjee   +6 more
wiley   +1 more source

Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation

Frontiers in Molecular Neuroscience, 2017
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system.
Rui P. A. Tan, Iryna Leshchyns’ka, Vladimir Sytnyk   +2 more
doaj   +1 more source

Artificial Synapse Network on Inorganic Proton Conductor for Neuromorphic Systems Applications [PDF]

, 2013
The basic units in our brain are neurons and each neuron has more than 1000 synapse connections. Synapse is the basic structure for information transfer in an ever-changing manner, and short-term plasticity allows synapses to perform critical computational functions in neural circuits.
arxiv   +1 more source

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Gorecki, Dariusz C., Krasowska, Elzbieta, Swinny, Jerome D., Zablocki, Krzysztof   +3 more
core   +2 more sources

Tin‐Based 2D/3D Perovskite Vertical Heterojunction for High‐Performance Synaptic Phototransistors

Advanced Functional Materials, EarlyView.
Phototransistors based on tin‐based 2D/3D perovskite heterostructures show an ultrahigh responsivity and detectivity at a low gate voltage across a broad wavelength region from ultraviolet to near‐infrared. The devices can replicate neuromorphic learning and remembering behaviors to light stimuli, in addition to electric depression and memory erasure ...
Hok‐Leung Loi, Tianyue Wang, Dapeng Liu, Jiupeng Cao, Jing Zhuang, Zeyu Zhao, Yang Xu, Mitch Guijun Li, Liang Li, Tianyou Zhai, Feng Yan   +10 more
wiley   +1 more source

Implementation of Multiple-Step Quantized STDP Based on Novel Memristive Synapses [PDF]

arXiv, 2023
Memristors have been widely studied as artificial synapses in neuromorphic circuits, due to their functional similarity with biological synapses, low operating power, and high integration density. In this work, a memristive synapse, composed of four memristors and two resistors, for SNN is designed and utilized for a neuron circuit implementing the ...
arxiv  

The Versatile Synapse [PDF]

Journal of Experimental Biology, 1984
ABSTRACT‘Typically’ chemical synaptic transmission takes place when an influx of calcium ions during a presynaptic nerve impulse triggers exocytosis of neurotransmitter substance from synaptic vesicles. The neurotransmitter diffuses across the synaptic cleft and occupies receptors embedded in the subsynaptic membrane.
openaire   +3 more sources