A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
Chromosoma, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Monica Faieta +9 more
semanticscholar +10 more sources
Cells, 2021 Meiosis involves a series of specific chromosome events, namely homologous synapsis, recombination, and segregation. Disruption of either recombination or synapsis in mammals results in the interruption of meiosis progression during the first meiotic ...
Roberto de la Fuente +10 more
doaj +2 more sources
The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
Nature Communications, 2019 During a process termed synapsis, the two DNA ends at a double-strand break (DSB) are brought together into physical proximity. Here, the authors use a single-molecule FRET approach with purified proteins to investigate the mechanism of synapsis in DSB ...
Bailin Zhao +5 more
doaj +2 more sources
A Study of Synapsis and Reduction
Bulletin of the Torrey Botanical Club, 1906 "From the Bulletin of the Torrey botanical club 33: 271-306, pl. 12-15, 1906" ; Thesis (Ph. D.)--Columbia University. ; "Literature": p. 297-303. ; Mode of access: Internet.
Ira Detrich Cardiff
openalex +3 more sources
The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans [PDF]
eLifeMeiotic crossover recombination is essential for both accurate chromosome segregation and the generation of new haplotypes for natural selection to act upon. This requirement is known as crossover assurance and is one example of crossover control.
Bhumil Patel +5 more
doaj +2 more sources
All Paired Up with No Place to Go: Pairing, Synapsis, and DSB Formation in a Balancer Heterozygote. [PDF]
PLoS Genetics, 2005 The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog.
Wei J Gong, Kim S McKim, R Scott Hawley
doaj +4 more sources
Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage [PDF]
bioRxiv, 2019 Meiosis is conserved across eukaryotes yet varies in the details of its execution. Here we describe a new comparative model system for molecular analysis of meiosis, the nematode Pristionchus pacificus, a distant relative of the widely studied model ...
Regina Rillo-Bohn +11 more
openalex +2 more sources
Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans [PDF]
Journal of Cell Biology, 2015 In C. elegans, a meiotic checkpoint monitors synapsis between homologous chromosomes. Mad1, Mad2, and Bub3 are required for this checkpoint and negatively regulate synapsis, suggesting a possible role for these proteins in monitoring the stability of ...
Tisha Bohr +3 more
openalex +2 more sources
Direct Visualization Reveals Kinetics of Meiotic Chromosome Synapsis.
Cell Reports, 2015 The synaptonemal complex (SC) is a conserved protein complex that stabilizes interactions along homologous chromosomes (homologs) during meiosis. The SC regulates genetic exchanges between homologs, thereby enabling reductional division and the production of haploid gametes.
O. Rog, A. Dernburg
semanticscholar +7 more sources