Results 1 to 10 of about 26,734 (323)
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
Chromosoma, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco +9 more
core +12 more sources
The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
Nature Communications, 2019 During a process termed synapsis, the two DNA ends at a double-strand break (DSB) are brought together into physical proximity. Here, the authors use a single-molecule FRET approach with purified proteins to investigate the mechanism of synapsis in DSB ...
Bailin Zhao +2 more
exaly +3 more sources
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis [PDF]
Cell, 2014 Michael A Lampson, Roger A Greenberg
exaly +3 more sources
PLoS Genetics, 2021 Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and ...
Alice Devigne, Needhi Bhalla
doaj +2 more sources
ZIP4 is required for normal progression of synapsis and for over 95% of crossovers in wheat meiosis
Frontiers in Plant Science, 2023 Tetraploid (AABB) and hexaploid (AABBDD) wheat have multiple sets of similar chromosomes, with successful meiosis and preservation of fertility relying on synapsis and crossover (CO) formation only taking place between homologous chromosomes.
Tracie N. Draeger +6 more
doaj +2 more sources
Cells, 2021 Meiosis involves a series of specific chromosome events, namely homologous synapsis, recombination, and segregation. Disruption of either recombination or synapsis in mammals results in the interruption of meiosis progression during the first meiotic ...
Roberto de la Fuente +10 more
doaj +2 more sources
All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote. [PDF]
PLoS Genetics, 2005 The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog.
Wei J Gong, Kim S McKim, R Scott Hawley
doaj +3 more sources
Science Advances, 2020 Synaptonemal complex assembly depends on multivalent protein interactions between SYCE1 and SIX6OS1. Meiotic reductional division depends on the synaptonemal complex (SC), a supramolecular protein assembly that mediates homologous chromosomes synapsis ...
Fernando Sánchez-Sáez +2 more
exaly +2 more sources
Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3
Nature Structural & Molecular Biology, 2023 SYCP1 structures are conformationally remodeled by molecular adapter SYCE3 to assemble into the supramolecular synaptonemal complex that mediates chromosome synapsis and facilitates crossover formation in meiosis.
James H. Crichton +7 more
openalex +3 more sources
Dual effect of the wheat Ph1 locus on chromosome synapsis and crossover
Chromosoma, 2017 Allopolyploids must possess a mechanism for facilitating synapsis and crossover (CO) between homologues, in preference to homoeologues (related chromosomes), to ensure successful meiosis.
María-Dolores Rey +2 more
exaly +3 more sources