DNA end configurations dictate synaptic complex formation during NHEJ-mediated end bridging [PDF]
Nature CommunicationsSynapsis, the physical bridging of two broken DNA ends, is a critical step in non-homologous DNA end joining (NHEJ), the primary pathway for repairing DNA double-strand breaks (DSBs) in vertebrates.
Chenyang Zhang +9 more
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Accumulation of ph1 (zip4-5B) and ph2 (msh7-3D) mutations fails to boost homoeologous recombination in hexaploid wheat [PDF]
Frontiers in Plant ScienceDiversification of the hexaploid (bread) wheat genetic pool using wild genetic resources relies on effective meiotic recombination (crossover) between wheat chromosomes and their counterparts from related species (homoeologues).
Camille Haquet +9 more
doaj +2 more sources
Somatic Kitl promotes mTOR to facilitate prophase I of meiosis in female embryonic gonads [PDF]
Cell Death and DiseaseHomologous synapsis and recombination are the central events that take place in the prophase I of meiosis. Signaling that promotes the germ cell differentiation and prophase I remains elusive.
Chang Liu +11 more
doaj +2 more sources
The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
Nature Communications, 2019 During a process termed synapsis, the two DNA ends at a double-strand break (DSB) are brought together into physical proximity. Here, the authors use a single-molecule FRET approach with purified proteins to investigate the mechanism of synapsis in DSB ...
Bailin Zhao +2 more
exaly +2 more sources
Speedy A governs non-homologous XY chromosome desynapsis as a unique prerequisite for XY loop-axis organization [PDF]
The EMBO JournalIn mouse early pachytene spermatocytes, the X and Y chromosomes undergo rapid non-homologous (NH) synapsis and desynapsis, but the functional significance remains unknown.
Dongteng Liu +18 more
doaj +2 more sources
Transcriptomic profile of epileptic children treated with ketogenic therapies [PDF]
Journal of Integrative Neuroscience, 2022 Background: Ketogenic dietary therapies (KDT) are used as a treatment in childhood epilepsy. However, their mechanism has not yet been established. The main objective of this study was to determine the changes in the transcriptomic profile induced by ...
Jana Ruiz-Herrero +8 more
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PLoS Genetics, 2021 Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and ...
Alice Devigne, Needhi Bhalla
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The Absence of Caspase-8 in the Dopaminergic System Leads to Mild Autism-like Behavior
Frontiers in Cell and Developmental Biology, 2022 In the last decade, new non-apoptotic roles have been ascribed to apoptotic caspases. This family of proteins plays an important role in the sculpting of the brain in the early stages of development by eliminating excessive and nonfunctional synapses and
I. Suárez-Pereira +15 more
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Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis. [PDF]
PLoS Genetics, 2013 Reduction in ploidy to generate haploid gametes during sexual reproduction is accomplished by the specialized cell division program of meiosis. Pairing between homologous chromosomes and assembly of the synaptonemal complex at their interface (synapsis ...
Susanna Mlynarczyk-Evans +2 more
doaj +1 more source
Regulation of microglia phagocytosis and potential involvement of exercise
Frontiers in Cellular Neuroscience, 2022 Microglia are considered the main phagocytic cells in the central nervous system, remodeling neural circuits by pruning synapses during development. Microglial phagocytosis is also a crucial process in maintaining adult brain homeostasis and clearing ...
Congqin Li +10 more
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