Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Regulation of microglia phagocytosis and potential involvement of exercise
Frontiers in Cellular Neuroscience, 2022 Microglia are considered the main phagocytic cells in the central nervous system, remodeling neural circuits by pruning synapses during development. Microglial phagocytosis is also a crucial process in maintaining adult brain homeostasis and clearing ...
Congqin Li +10 more
doaj +1 more source
Privación sensorial temprana durante el neurodesarrollo y sus consecuencias cognitivas
Medicina U.P.B., 2020 La aparición progresiva de habilidades sensoriales, motoras y cognitivo-afectivas en el humano a lo largo de su desarrollo es un reflejo de cambios fisiológicos que se gestan al interior del sistema nervioso.
Juan Felipe Álvarez Restrepo +1 more
doaj +1 more source
Frontiers in Plant Science, 2020 Hybridization and polyploidization are major driving forces in plant evolution. Allopolyploids can be occasionally formed from a cross between distantly related species but often suffer from chromosome instability and infertility. xBrassicoraphanus is an
Hye Rang Park +15 more
doaj +1 more source
ZIP4 is required for normal progression of synapsis and for over 95% of crossovers in wheat meiosis
Frontiers in Plant Science, 2023 Tetraploid (AABB) and hexaploid (AABBDD) wheat have multiple sets of similar chromosomes, with successful meiosis and preservation of fertility relying on synapsis and crossover (CO) formation only taking place between homologous chromosomes.
Tracie N. Draeger +6 more
doaj +1 more source
Tau oligomers: the toxic player at synapses in Alzheimer’s disease
Frontiers in Cellular Neuroscience, 2015 Alzheimer’s disease (AD) is a progressive disorder in which the most noticeable symptoms are cognitive impairment and memory loss. However, the precise mechanism by which those symptoms develop remains unknown.
Marcos Jair Guerrero-Munoz +2 more
doaj +1 more source
Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. [PDF]
PLoS Genetics, 2012 Meiotic recombination and chromosome synapsis between homologous chromosomes are essential for proper chromosome segregation at the first meiotic division. While recombination and synapsis, as well as checkpoints that monitor these two events, take place
Tomoyuki Fukuda +5 more
doaj +1 more source
Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.
PLoS Genetics, 2019 During meiosis, each chromosome must selectively pair and synapse with its own unique homolog to enable crossover formation and subsequent segregation.
Talia Hatkevich +5 more
doaj +1 more source
Cells, 2021 Meiosis involves a series of specific chromosome events, namely homologous synapsis, recombination, and segregation. Disruption of either recombination or synapsis in mammals results in the interruption of meiosis progression during the first meiotic ...
Roberto de la Fuente +10 more
doaj +1 more source
Dynamics of rye chromosome 1R regions with high or low crossover frequency in homology search and synapsis development. [PDF]
PLoS ONE, 2012 In many organisms, homologous pairing and synapsis depend on the meiotic recombination machinery that repairs double-strand DNA breaks (DSBs) produced at the onset of meiosis.
Nohelia T Valenzuela +2 more
doaj +1 more source