Chromosome segregation in plant meiosis [PDF]
Frontiers in Plant Science, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
Linda eZamariola +4 more
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Transcriptomic profile of epileptic children treated with ketogenic therapies [PDF]
Journal of Integrative Neuroscience, 2022 Background: Ketogenic dietary therapies (KDT) are used as a treatment in childhood epilepsy. However, their mechanism has not yet been established. The main objective of this study was to determine the changes in the transcriptomic profile induced by ...
Jana Ruiz-Herrero +8 more
doaj +1 more source
The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast [PDF]
, 2013 During meiosis, homologous chromosomes pair at close proximity to form the synaptonemal complex (SC). This association is mediated by transverse filament proteins that hold the axes of homologous chromosomes together along their entire length. Transverse
AB Zavec +56 more
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Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3
Nature Structural & Molecular Biology, 2023 SYCP1 structures are conformationally remodeled by molecular adapter SYCE3 to assemble into the supramolecular synaptonemal complex that mediates chromosome synapsis and facilitates crossover formation in meiosis.
James H. Crichton +7 more
semanticscholar +1 more source
SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis
Science Advances, 2023 In almost all sexually reproducing organisms, meiotic recombination and cell division require the synapsis of homologous chromosomes by a large proteinaceous structure, the synaptonemal complex (SC).
K. K. Billmyre +11 more
semanticscholar +1 more source
DNA double-strand break end synapsis by DNA loop extrusion
bioRxiv, 2021 DNA double-strand breaks (DSBs) occur every cell cycle and must be efficiently repaired. Non-homologous end joining (NHEJ) is the dominant pathway for DSB repair in G1-phase.
Jin Yang, Hugo B. Brandão, A. Hansen
semanticscholar +1 more source
Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations
Frontiers in Pharmacology, 2022 Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory ...
Triana Espinosa-Jiménez +33 more
doaj +1 more source
PLoS Genetics, 2021 Meiotic homolog synapsis is essential to ensure accurate segregation of chromosomes during meiosis. In C. elegans, proper regulation of synapsis and a checkpoint that monitors synapsis relies on the spindle checkpoint components, Mad1 and Mad2, and ...
Alice Devigne, Needhi Bhalla
doaj +1 more source
Evidence that masking of synapsis imperfections counterbalances quality control to promote efficient meiosis. [PDF]
PLoS Genetics, 2013 Reduction in ploidy to generate haploid gametes during sexual reproduction is accomplished by the specialized cell division program of meiosis. Pairing between homologous chromosomes and assembly of the synaptonemal complex at their interface (synapsis ...
Susanna Mlynarczyk-Evans +2 more
doaj +1 more source
The F-Box Protein ZYGO1 Mediates Bouquet Formation to Promote Homologous Pairing, Synapsis, and Recombination in Rice Meiosis [PDF]
The Plant Cell, 2017 Fanfan Zhang +8 more
openalex +2 more sources