The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation in Caenorhabditis elegans [PDF]
eLifeMeiotic crossover recombination is essential for both accurate chromosome segregation and the generation of new haplotypes for natural selection to act upon. This requirement is known as crossover assurance and is one example of crossover control.
Bhumil Patel +5 more
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Moving and stopping: Regulation of chromosome movement to promote meiotic chromosome pairing and synapsis [PDF]
The Nucleus, 2017 Meiosis is a specialized cellular division occurring in organisms capable of sexual reproduction that leads to the formation of gametes containing half of the original chromosome number.
Benjamin Alleva, Sarit Smolikove
openalex +2 more sources
The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure [PDF]
Molecules and Cells, 2017 Vera D. Rinaldi +4 more
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Chromosome segregation in plant meiosis [PDF]
Frontiers in Plant Science, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
Linda eZamariola +4 more
doaj +4 more sources
Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair. [PDF]
Biophys RepJiang Y +5 more
europepmc +2 more sources
The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation and promotes crossover assurance. [PDF]
, 2013 For most organisms, chromosome segregation during meiosis relies on deliberate induction of DNA double-strand breaks (DSBs) and repair of a subset of these DSBs as inter-homolog crossovers (COs).
Dernburg, Abby +6 more
core +18 more sources
Improved synapsis dynamics accompany meiotic stability in <i>Arabidopsis arenosa</i> autotetraploids. [PDF]
Proc Natl Acad Sci U S AGonzalo A, Nayak A, Bomblies K.
europepmc +3 more sources
Transcriptomic profile of epileptic children treated with ketogenic therapies [PDF]
Journal of Integrative Neuroscience, 2022 Background: Ketogenic dietary therapies (KDT) are used as a treatment in childhood epilepsy. However, their mechanism has not yet been established. The main objective of this study was to determine the changes in the transcriptomic profile induced by ...
Jana Ruiz-Herrero +8 more
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SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis
Science Advances, 2023 In almost all sexually reproducing organisms, meiotic recombination and cell division require the synapsis of homologous chromosomes by a large proteinaceous structure, the synaptonemal complex (SC).
K. K. Billmyre +11 more
semanticscholar +1 more source
Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations
Frontiers in Pharmacology, 2022 Peroxisome proliferator-activated receptor β/δ (PPARβ/δ), the most PPAR abundant isotype in the central nervous system, is involved in microglial homeostasis and metabolism, whose disturbances have been demonstrated to play a key role in memory ...
Triana Espinosa-Jiménez +33 more
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